Bojidarka Ivanov

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The electronic structures, optical properties and molecular structures of a series of isoquinoline alkaloids resulting in the formation of papaverine, through a proposed biosynthetic pathway via S(+)-reticuline were elucidated. The mechanism of papaverine synthesis was studied by electronic absorption, diffuse reflectance, fluorescence and CD spectroscopy,(More)
Ki, Km and kcat. constants which characterize the interaction with pepsin of a complete series of Ac-Leu-Tyr-NHMe and Ac-Tyr-Leu-NHMe stereoisomers are determined. In compounds, containing residues of different configuration, Ki was found to have higher values than Ki or Km in DD- and LL-dipeptides. The data obtained show that not only the rate of peptide(More)
Reactive phosphonate diesters were designed and prepared as inhibitors of serine proteases and esterases. Inactivation of trypsin, chymotrypsin, and butyrylcholinesterase was determined by residual enzymatic activity as well as by the release of a chromogenic or fluorogenic product of the inhibition reaction. Second-order rate constants were determined from(More)
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