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UNLABELLED Oxidative and carbonyl stress may, on one hand, contribute to the progression of cancer, on the other hand, they may have some antiproliferative effects. We examined serum levels of AGEs (advanced glycation end-products), CML (carboxymethyllysine) and AOPP (advanced oxidation protein products) in 86 patients with breast cancer subdivided based on(More)
Intermittent hypobaric hypoxia induces functional and morphological changes of the brain in 25-day-old rats. Administration of magnesium has partial pro-convulsion effect in hypoxia not exposed rats and it practically does not influence the excitability of cortical neurones in rats exposed to intermittent hypoxia. Magnesium administration decreases the(More)
Platelet fibrin(ogen) adhesive interactions were investigated in whole citrated blood using the rectangular perfusion chamber at wall shear rates of 300 and 1600 s(-1) with regard to the amount and structure of immobilized protein. Only single platelets adhered to adsorbed fibrinogen at both low and high surface fibrinogen concentrations and at 1600 s(-1)(More)
OBJECTIVES The purpose of the present study was to determine changes of biochemical risk factors of thromboembolism especially of TFPI during the use of oral versus transdermal administration of early estrogen replacement therapy. METHODS In a 12-week prospective, randomized, cross-over trial, oestradiol was administered orally in a dose of 2 mg daily or(More)
OBJECTIVE The aim of study was to evaluate changes of lipid profil during different types of estrogen replacement therapy (ERT). DESIGN Prospective randomized study. SETTING 1st Faculty of Medicine and General Faculty Hospital Prague. METHODS Two routes of administration were used for 12 weeks: oral estradiol 2 mg/day and transdermal estradiol 50(More)
OBJECTIVE The purpose of the present study was to determine changes of tissue factor pathway inhibitor (TFPI) as a biochemical risk factors of thromboembolism during the use of different administration methods of the early estrogen replacement therapy. DESIGN Prospective randomized cross-over trial. SETTING General Faculty Hospital Prague. METHODS In(More)
The study summarizes the results obtained during personal visits to 53 medical schools in the 13 original EU countries during 2004--2006. Data from the Czech Republic is shown for comparison. The possibilities of acquiring information from the websites of the medical schools in the local language and English are assessed. The admission process to medical(More)
BACKGROUND C-reactive protein is one of the independent risk factors of cardiovascular diseases. The aim of study was to find changes of hsCRP levels during transdermal and oral application of estrogen replacement therapy. METHODS AND RESULTS Two application ways were used for 12 weeks: oral estradiol 2 mg/day and transdermal estradiol 50 microg /day(More)
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