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Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines
TLDR
The antiproliferative assay demonstrated that centaureidin is the most effective constituent of the aerial parts of yarrow: high cell growth inhibitory activities were observed especially on HeLa and MCF‐7 cells, which is the first report on the occurrence of seco‐pseudoguaianolides in the Achillea genus. Expand
Inhibition of COX-2 and NF-κB1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium.
TLDR
It was found that O. acanthium extracts exert strong inhibitory activities in vitro and some lignans, flavonoids, and sesquiterpenes may play a role in these activities. Expand
Antiproliferative constituents of the roots of Conyza canadensis.
TLDR
Some of the active components of the isolated compounds proved to be substantially more potent against these cell lines than against noncancerous human foetal fibroblasts (MRC-5) and can therefore be considered selective antiproliferative natural products. Expand
Bioactivity-guided Isolation of Antiproliferative Compounds from the Roots of Onopordum acanthium
TLDR
4β,14-dihydro-3-dehydrozaluzanin C (1), the most active antiproliferative compound of the extract, exerted remarkable tumor cell growth inhibitory activity (IC50 2.7–15.1 μM). Expand
Antiproliferative and Antimicrobial Activities of Selected Bryophytes
TLDR
From the tested families, Brachytheciaceae and Amblystegiaceae provided the highest number of antiproliferative extracts and only 19 samples of 15 taxa showed moderate antibacterial activity, including the most active Plagiomnium cuspidatum, being active on 8 tested strains. Expand
Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II
TLDR
High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than direct killing effects, were found for some Centaurea, Cirsium, Cichorium, Lactuca, Onopordum and Scorsonera extracts. Expand
Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
TLDR
The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity. Expand
Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I
TLDR
Eleven of the tested 25 plants were found to be active and 4 of them had not been studied previously for either active compounds or anticancer properties, and their direct cytotoxic effects were determined. Expand
Investigation of the Antiproliferative Properties of Natural Sesquiterpenes from Artemisia asiatica and Onopordum acanthium on HL-60 Cells in Vitro
TLDR
Experimental results indicate that sesquiterpene lactones may be regarded as potential starting structures for the development of novel anticancer agents. Expand
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