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Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist.
Vascular endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis that are up-regulated by hypoxia. We evaluated the effects of DNA-binding smallExpand
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Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells
Significance Cell-based approaches utilizing retinal pigment epithelial (RPE)-like cells derived from human pluripotent stem cells (hPSCs) are being developed for the treatment of retinalExpand
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Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances.
Targeting of drugs and their carrier systems by using receptor-mediated endocytotic pathways was in its nascent stages 25 years ago. In the intervening years, an explosion of knowledge focused onExpand
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Completion of a Programmable DNA-Binding Small Molecule Library.
Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-bindingExpand
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In vivo anticancer activity of rhomboidal Pt(II) metallacycles
Significance The design of new antitumor agents and the search for delivery vehicles for existing drugs are two problems in cancer therapy that are often solved separately. Drug delivery vehicles areExpand
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Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix.
Designed ligands that inhibit hypoxia-inducible gene expression could offer new tools for genomic research and, potentially, drug discovery efforts for the treatment of neovascularization in cancers.Expand
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A selective mitochondrial-targeted chlorambucil with remarkable cytotoxicity in breast and pancreatic cancers.
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive toExpand
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In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics
Significance Protein–protein interactions are attractive targets for drug design due to their fundamental role in biological function. However, small molecules that selectively target the intendedExpand
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Monoamine oxidase A inhibitor-near-infrared dye conjugate reduces prostate tumor growth.
Development of anti-cancer agents with high tumor-targeting specificity and efficacy is critical for modern multidisciplinary cancer research. Monoamine oxidase A (MAOA), a mitochondria-bound enzyme,Expand
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Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex.
Hypoxia is a hallmark of solid tumors, is associated with local invasion, metastatic spread, resistance to chemo- and radiotherapy, and is an independent, negative prognostic factor for a diverseExpand
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