Bogdan Istrate

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Transient protein-protein interactions (PPIs), which underly most biological processes, are a prime target for therapeutic development. Immense progress has been made towards computational prediction of PPIs using methods such as protein docking and sequence analysis. However, docking generally requires high resolution structures of both of the binding(More)
Interaction sites on protein surfaces mediate virtually all biological activities, and their identification holds promise for disease treatment and drug design. Novel algorithmic approaches for the prediction of these sites have been produced at a rapid rate, and the field has seen significant advancement over the past decade. However, the most current(More)
Surface area as derived by MSMS [1] was obtained per residue and then divided by the solvent excluded surface area of the mean maximum residue surface area (MMRSA) for the residue's type. The MMRSA was calculated using UCSF Chimera [2], simulating each residue in a GLY-X-GLY tri-peptide and averaging surface area values over 5 different secondary structures(More)
  • MYASTHENIA GRAVIS, IN PEDIATRICS, B Istrate
  • 2011
Myasthenia Gravis is a chronic autoimmune neuromuscular disorder characterized by abnormal fatigability of muscle after repeated or sustained activity and improvement after rest. Peak incidence is seen in young adults but it may also occur in infancy and childhood. Three separate entities are characteristic in childhood period (a) transient neonatal(More)
The significance of neuroimmune mechanisms in triggering of some neuro psychiatric disorders in child, comprises an important aspect, although little discussed, that should be brought to the attention of the clinician. The impact of the interactions between the nervous and immune system is not standing alone being neurochemical and neuroendocrine mediated.(More)
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