Bogdan Istrate

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Transient protein-protein interactions (PPIs), which underly most biological processes, are a prime target for therapeutic development. Immense progress has been made towards computational prediction of PPIs using methods such as protein docking and sequence analysis. However, docking generally requires high resolution structures of both of the binding(More)
Interaction sites on protein surfaces mediate virtually all biological activities, and their identification holds promise for disease treatment and drug design. Novel algorithmic approaches for the prediction of these sites have been produced at a rapid rate, and the field has seen significant advancement over the past decade. However, the most current(More)
Surface area as derived by MSMS [1] was obtained per residue and then divided by the solvent excluded surface area of the mean maximum residue surface area (MMRSA) for the residue's type. The MMRSA was calculated using UCSF Chimera [2], simulating each residue in a GLY-X-GLY tri-peptide and averaging surface area values over 5 different secondary structures(More)
The significance of neuroimmune mechanisms in triggering of some neuro psychiatric disorders in child, comprises an important aspect, although little discussed, that should be brought to the attention of the clinician. The impact of the interactions between the nervous and immune system is not standing alone being neurochemical and neuroendocrine mediated.(More)
Glaucoma is one of the most frequent causes of vision loss and blindness. The increased intraocular pressure does not explain glaucoma in all patients but can be considered as a risk factor of the disease. It seems that systemic immunity of the eye through up-and-down immunological regulation of autoantibodies against ocular antigens make their impact felt(More)
Generally speaking, the uveitis comprises a relative complex group of autoimmune diseases or other autoimmune associated illness. Until now, a little from molecular and cellular mechanisms are known in the autoimmunity of uveitis. The uveitis may cause a visual handicap as well, leading even to blindness. This paper tries to bring into focus some of the(More)
  • 2011
Myasthenia Gravis is a chronic autoimmune neuromuscular disorder characterized by abnormal fatigability of muscle after repeated or sustained activity and improvement after rest. Peak incidence is seen in young adults but it may also occur in infancy and childhood. Three separate entities are characteristic in childhood period (a) transient neonatal(More)
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