Bogdan I. Epureanu

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An intriguing and unexpected result for students learning numerical analysis is that Newton's method, applied to the simple polynomial z 3 − 1 = 0 in the complex plane, leads to intricately interwoven basins of attraction of the roots. As an example of an interesting open question that may help to stimulate student interest in numerical analysis, we(More)
Renewal-reward processes are used to provide a framework for the mathematical description of single-molecule bead-motor assays for processive motor proteins. The formulation provides a more powerful, general approach to the fluctuation analysis of bead-motor assays begun by Svoboda et al. (Proc. Natl. Acad. Sci. USA 91(25):11782, 1994). Fluctuation analysis(More)
Motor proteins are biological enzymes that convert chemical energy to mechanical work in cells. Kinesin-1 is a motor protein that transports vesicles along microtubules and is widely believed to be responsible for anterograde transport of synaptic vesicles in neurons. Advances in single-molecule techniques have shown that single kinesin motors are capable(More)
Forecasting bifurcations before they occur is a significant challenge and an important need in several fields. Existing approaches detect bifurcations before they occur by exploiting the critical slowing down phenomenon. However, the perturbations used in those approaches are limited to being very small and this represents a significant drawback. Large(More)
Kinesins are molecular motors which transport various cargoes in the cytoplasm of cells and are involved in cell division. Previous models for kinesins have only targeted their in vitro motion. Thus, their applicability is limited to kinesin moving in a fluid with low viscosity. However, highly viscoelastic fluids have considerable effects on the movement(More)
A damage detection method is developed for nonlinear systems using model updating. The method uses a nonlinear discrete model of the system and the form of the nonlinearities to create an augmented linear model of the system. A modal analysis technique that uses forcing that is known but not prescribed is then used to solve for the modal properties of the(More)
Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads. However, kinesins perform much longer range transport in cells by working collectively. This long range of transport by a team of kinesins is surprising because the(More)
The dynamic responses of a thermo-shielding panel forced by unsteady aerodynamic loads and a classical Duffing oscillator are investigated to detect structural damage. A nonlinear aeroelastic model is obtained for the panel by using third-order piston theory to model the unsteady supersonic flow, which interacts with the panel. To identify damage, we(More)
Kinesin is a processive molecular motor which transports various cellular cargos by converting chemical energy into mechanical movements. Although the motion of a single molecule has been characterized in several studies, the dynamics of collective transport remains controversial. Since the chemical reactions fueling molecular motors are stochastic(More)