Bogdan Cylwik

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Chronic alcohol consumption increases body iron stores. Patients with alcoholic liver disease frequently exhibit iron overload, but mechanisms of its accumulation remain unclear. Many novel iron-regulatory proteins have been identified for several last years, which have improved understanding the underlying some mechanisms of iron overload in alcoholic(More)
BACKGROUND Previous studies have shown that serum total sialic acid (TSA) concentration significantly increases during alcohol abuse. Chronic ethanol consumption impairs glycosylation of many proteins. The increased desialylation rate of serum glycoproteins is one of the effects of alcohol abuse. The aim of this study was to investigate the diagnostic value(More)
Glycosylation is the most common chemical process of protein modification and occurs in every living cell. Disturbances of this process may be either congenital or acquired. Congenital disorders of glycosylation (CDG) are a rapidly growing disease family, with about 50 disorders reported since its first clinical description in 1980. Most of the human(More)
BACKGROUND Cell adhesion molecules and endothelial growth factors have an important role in the infiltrating of rheumatoid synovium with mononuclear cells, leading to the initiation and progression of the disease. OBJECTIVE To investigate whether the serum profile of soluble adhesion molecules and of vascular endothelial growth factor (VEGF) is associated(More)
The objective of this study was to compare the diagnostic power of direct carbohydrate-deficient transferrin (CDT) immunoassay in alcohol abuse expressed in relative units with the diagnostic power of the results expressed in absolute units. Serum CDT was determined in 127 alcoholics using N Latex CDT direct immunonephelometric assay (Siemens Healthcare(More)
Glycosylation is a form of post-translational modification of proteins and occurs in every living cell. The carbohydrate chains attached to the proteins serve various functions. There are two main types of protein glycosylation: N-glycosylation and O-glycosylation. In this paper, we describe the O-glycosylation process and currently known congenital(More)
This study has investigated the serum levels of carbohydrate-deficient isoforms of transferrin (CDT) and sialic acid (SA) in iron-deficiency anemia (IDA). Blood samples were collected from 60 women with IDA and from 20 healthy controls. CDT was estimated by anion-exchange chromatography on minicolumns followed by photometric detection of transferrin and was(More)
OBJECTIVE Rheumatoid arthritis (RA) is characterized by an invasive and tissue destructive infiltrate of lymphocytes, macrophages, and synoviocytes formed in the joints. Its etiopathogenesis and the role of the particular morphological components of synovitis remain unclear. There is evidence that its histological heterogeneity is correlated with synovium(More)
OBJECTIVE Rheumatoid synovitis is characterized by an invasive and tissue-destructive infiltrate of lymphocytes, macrophages and synoviocytes. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) produced by these cells are important in the remodelling of the articular tissues in rheumatoid arthritis (RA). The aim of this(More)
PURPOSE The aim of this study was to assess the relationship between serum acute-phase proteins and high disease activity evaluated by activity score (DAS28) in patients with rheumatoid arthritis. MATERIAL/METHODS Studies were carried out on 27 females with RA and 32 control women. Acute-phase proteins were divided into 4 fractions as follows:(More)