Bodil Lund Jacobsen

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We have developed very efficient suicide functions for biological containment based on the lethal Escherichia coli relF gene. The suicide functions are placed in duplicate within a plasmid and arranged to prevent inactivation by deletion, recombination, and insertional inactivation. The efficiency of this concept was tested in a plasmid containment system(More)
A new animal model, the streptomycin-treated mini-pig, was developed in order to allow colonization of defined strains of Enterococcus faecalis in numbers sufficient to study plasmid transfer. Transfer of the pheromone-inducible pCF10 plasmid between streptomycin-resistant strains of E. faecalis OG1 was investigated in the model. The plasmid encodes(More)
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antimicr antimicr antimicr antimicrobial obial obial obial obial a a a a ag g g g gents and occur ents and occur ents and occur ents and occur ents and occurr r r r rence of ence of ence of ence of ence of antimicr antimicr antimicr antimicr antimicrobial obial obial obial obial r r r r resistance in bacteria fr esistance in bacteria fr esistance in(More)
Inulin-type fructans, which are nondigestible carbohydrates, have been shown to modulate the number of induced preneoplastic lesions in the colon as well as the colonic microflora in laboratory animals. The present study was designed to investigate the effect of a short- and long-chained inulin-type fructan on 1,2-dimethylhydrazine dihydrochloride-induced(More)
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