Bobby Heydari

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BACKGROUND Animal studies have shown that neuroactive steroids modulate the activity of the gamma-aminobutyric acid type A/benzodiazepine receptor complex and that these steroids display anxiolytic or anxiogenic activity depending on their positive (e.g. allopregnanolone) or negative allosteric modulation (e.g. dehydroepiandrosterone sulphate) of this(More)
Background Recent studies suggest that central obesity and insulin resistance may be primary mediators of obesity-related cardiac remodeling independent of body mass index (BMI). We assessed in the Multi-Ethnic Study of Atherosclerosis (MESA) whether insulin resistance and waist-to-hip ratio had effects on cardiac remodeling, independent of obesity. Methods(More)
PURPOSE To evaluate the feasibility of accelerated cardiac MR (CMR) perfusion with radial sampling using nonlinear image reconstruction after exercise on an MR-compatible supine bike ergometer. METHODS Eight healthy subjects were scanned on two separate days using radial and Cartesian CMR perfusion sequences in rest and exercise stress perfusion. Four(More)
Effect of purified omega-3 fatty acids on reducing left ventricular remodeling after acute myocardial infarction (OMEGA-REMODEL study): a double-blind randomized clinical trial) Bobby Heydari, Siddique A Abbasi, Ravi Shah, Shuaib Abdullah, Jiazuo Feng, William Harris, Joe McConnell, Evan Appelbaum, Udo Hoffmann, Michael Steigner, Ron Blankstein, Elliott A(More)
Methods From 2003-2011, 707 patients underwent CMR-MPI for ischemia assessment in our center. Estimated pre-test cardiac risk derived from a combined Framingham Heart Study and Diamond Forrester risk percentage was used to match CMR patients against 39,876 patients who underwent pharmacologic stress SPECT in another tertiary-care center during the same time(More)
Background Changes in left ventricular compliance caused by diffuse fibrosis after MI may result in diastolic dysfunction and left atrial enlargement. We sought to test the hypothesis that left atrial volume is associated with ECV (a marker of diffuse myocardial fibrosis) during the sub-acute phase of infarction and can predict the increase of ECV during(More)
Introduction While LVEF is the current most robust marker of mortality in pts with chronic CAD, an improved risk stratification method is necessary for guidance of medical or ICD therapy. Peri-infarct zone (PIZ) as a marker of infarcted heterogeneity has been associated with arrythmogenic substrates and reduced post-MI survival. However, the prognostic(More)
Background Late gadolinium enhancement (LGE) during contrastenhanced cardiac magnetic resonance (CMR) imaging is a powerful predictor of adverse event. However, there are limited data regarding the incidence and prognostic significance of LGE in patients with atrial fibrillation (AF). Furthermore, while CMR is one of the modalities employed in(More)
CMR quantification of infarct tissue heterogeneity and remote myocardial fibrotic burden during convalescent phase following acute myocardial infarction (MI) provided strong and complementary evidence of ventricular arrhythmogenicity from quantitative microvolt T-wave alternans testing (the NHLBI PROSPECT-CMR study) Bobby Heydari, Shuaib Abdullah, Evan(More)
Background Hypertension is associated with the development of myocardial fibrosis with a subsequent increase in the myocardial extracellular volume (ECV). T1 measurements pre and post a contrast cardiac magnetic resonance (CMR) study provide a robust non-invasive method for quantification of the ECV. We aimed to determine whether the CMR-derived ECV can(More)