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Mitochondria are the primary generators of cellular reactive oxygen species (ROS); their pathophysiological roles in hypertension and insulin resistance are but imperfectly understood. Mitochondrial dysfunction has been linked to the etiologies of many complex diseases, but many other factors, including the upregulation of the renin-angiotensin system (RAS)(More)
In order to assess the extent of xylazine (Xyz) injection in Puerto Rico, two waves of used-syringe collections were performed. In the first, syringes were gathered, anonymously and without additional information; in the second, a short interview, also anonymous, was administered. We found Xyz in 37.6% of the collected syringes; the majority of the(More)
The renin-angiotensin system (RAS) is classically known as a regulator of arterial pressure, which is accomplished by regulating the balance of water and sodium. This has led to the successful development of drugs such as anti-hypertensives that block the system. In addition, this system has a fundamental role in the mechanisms of inflammation and of(More)
It is advisable to refer to the publisher's version if you intend to cite from the work. Abstract The literature suggests the need for incorporating the risk construct into the measurement of organisational performance, although few examples are available as to how this might be undertaken in relation to supply chains. A conceptual framework for the(More)
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