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Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses…

• Patrick C Y Woo, Susanna K. P. Lau, +10 authors Kwok-yung Yuen
• Journal of virology
• 2012

Recently, we reported the discovery of three novel coronaviruses, bulbul coronavirus HKU11, thrush coronavirus HKU12, and munia coronavirus HKU13, which were identified as representatives of a novel… (More)

Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features.

• Patrick C Y Woo, Ming Wang, +12 authors Kwok-yung Yuen
• Journal of virology
• 2007

Twelve complete genomes of three novel coronaviruses-bat coronavirus HKU4 (bat-CoV HKU4), bat-CoV HKU5 (putative group 2c), and bat-CoV HKU9 (putative group 2d)-were sequenced. Comparative genome… (More)

Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute,…

• Susanna K. P. Lau, Kenneth S. M. Li, +11 authors Kwok-yung Yuen
• Journal of virology
• 2010

Despite the identification of severe acute respiratory syndrome-related coronavirus (SARSr-CoV) in Rhinolophus Chinese horseshoe bats (SARSr-Rh-BatCoV) in China, the evolutionary and possible… (More)

Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome.

• Susanna K. P. Lau, Patrick C. Y. Woo, +8 authors Kwok-yung Yuen
• Virology
• 2007

Apart from bat-SARS-CoV, we have identified a novel group 1 coronavirus, bat-CoV HKU2, in Rhinolophus sinicus (Chinese horseshoe bats). Since it has been suggested that the receptor-binding motif… (More)

Identification of influenza A nucleoprotein as an antiviral target

• Richard Yi-Tsun Tsun Kao, Dan Yang, +14 authors Kwok-yung Yuen
• Nature Biotechnology
• 2010

Influenza A remains a significant public health challenge because of the emergence of antigenically shifted or highly virulent strains. Antiviral resistance to available drugs such as adamantanes or… (More)

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

• Lanying Du, Yuxian He, Shuwen Liu, Bo-jian Zheng, Shibo Jiang
• Nature Reviews Microbiology
• 2009

Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike (S) protein is composed of two subunits;… (More)

Modification of nonstructural protein 1 of influenza A virus by SUMO1.

• Ke Xu, Christoph Klenk, +12 authors Bing Sun
• Journal of virology
• 2011

Nonstructural protein 1 (NS1) is one of the major factors resulting in the efficient infection rate and high level of virulence of influenza A virus. Although consisting of only approximately 230… (More)

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development.

• Lanying Du, Guangyu Zhao, +8 authors Shibo Jiang
• Journal of virology
• 2013

A novel human Middle East respiratory syndrome coronavirus (MERS-CoV) caused outbreaks of severe acute respiratory syndrome (SARS)-like illness with a high mortality rate, raising concerns of its… (More)

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

• Bao-jian Li, Qingquan Tang, +9 authors Patrick Y. Lu
• Nature Medicine
• 2005

Development of therapeutic agents for severe acute respiratory syndrome (SARS) viral infection using short interfering RNA (siRNA) inhibitors exemplifies a powerful new means to combat emerging… (More)

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

• Tianlei Ying, Lanying Du, +11 authors D. S. Dimitrov
• Journal of virology
• 2014

The recently discovered Middle East respiratory syndrome coronavirus (MERS-CoV) continues to infect humans, with high mortality. Specific, highly effective therapeutics and vaccines against the… (More)

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