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Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors.
Microglial cells rapidly become activated in response to even minor damage of neurons, suggestive of the intimate interactions between neurons and microglial cells. Although mediators forExpand
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Myeloid-Derived Suppressor Cells Regulate Immune Response in Patients with Chronic Hepatitis B Virus Infection through PD-1–Induced IL-10
Although myeloid-derived suppressor cells (MDSCs) are well known for their immunosuppressive function in several pathological conditions, the role of MDSCs in hepatitis B virus infection remainsExpand
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The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit
Glutamate-induced excitotoxicity has been implicated in the etiology of stroke, epilepsy, and neurodegenerative diseases. NMDA receptors (NMDARs) play a pivotal role in excitotoxic injury; however,Expand
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  • Open Access
Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing
Dyskeratosis congenita (DC) is a rare bone marrow failure syndrome in which hematopoietic defects are the main cause of mortality. The most studied gene responsible for DC pathogenesis is DKC1 whileExpand
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Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response
RationaleSerotonin transporter (5-HTT) and norepinephrine transporter (NET) are the primary targets of many antidepressants. We aimed to determine the potential correlations of 5-HTT/NET geneExpand
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Haff disease after eating crayfish in east China.
Haff disease, first identified in Europe, is unexplained rhabdomyolysis in a person who ingested fish within the 24 hours before onset of illness. Cases of Haff disease after the consumption of freshExpand
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  • Open Access
Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
Autophagy defect has been shown to be correlated with malignant phenotype and poor prognosis of human cancers, however, the detailed mechanisms remain obscure. In this study, we investigated theExpand
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  • Open Access
S-allylcysteine, a garlic derivative, suppresses proliferation and induces apoptosis in human ovarian cancer cells in vitro
Aim:To investigate the effects of S-allylcysteine (SAC), a water-soluble garlic derivative, on human ovarian cancer cells in vitro.Methods:Human epithelial ovarian cancer cell line A2780 was tested.Expand
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Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi) and its three processed products on mitochondrial growth
ETHNOPHARMACOLOGICAL RELEVANCE The crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi), together with its processed products, including Yanfuzi, Heishunpian and Paofupian, are commonlyExpand
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  • Open Access
Heme oxygenase is involved in cobalt chloride-induced lateral root development in tomato
In animals, heme oxygenase (HO), a rate-limiting enzyme responsible for carbon monoxide (CO) production, was regarded as a protective system maintaining cellular homeostasis. It was also establishedExpand
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