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Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors.
TLDR
The results suggest that norepinephrine participates in the regulation of brain function at least partly by modulating the functions of microglia. Expand
The DREAM Protein Negatively Regulates the NMDA Receptor through Interaction with the NR1 Subunit
TLDR
DREAM is revealed as a novel, negative regulator of NMDARs and provides an attractive candidate for the treatment of excitotoxicity-related disease. Expand
Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing
TLDR
It is demonstrated that hematopoietic defects are specifically recapitulated in these models and that these defects are significantly reduced in a p53 null mutant background, and it is shown that changes in telomerase activity are undetectable at the early stages of DC pathogenesis but rRNA processing is clearly defective. Expand
Myeloid-Derived Suppressor Cells Regulate Immune Response in Patients with Chronic Hepatitis B Virus Infection through PD-1–Induced IL-10
TLDR
For the first time, it is proved that CD14+HLA-DR–/lowPD-1+ MDSCs in CHB patients contribute to an inadequate immune response against the virus and lead to chronic infection, which represents a potential target for therapeutic intervention. Expand
Haff disease after eating crayfish in east China.
TLDR
Five cases of muscle weakness and rhabdomyolysis that occurred after eating crayfish in China are described and the different epidemiologic and etiologic aspects of this disease are discussed. Expand
Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells
TLDR
It is suggested that autophagy defect promotes metastasis and glycolysis of Gastric cancer, and antioxidants could be used to improve disease outcome for gastric cancer patients with autophagic defect. Expand
Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity.
TLDR
Results suggested that the neuroprotective effects of shikonin against cerebral ischemia/reperfusion injury may be attributed to its antioxidant effects. Expand
Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response
TLDR
A positive association of the NET-T182C polymorphism with susceptibility to and severity of depression, and a positive association between the 5-HTT polymorphisms and the antidepressant response to SSRI are revealed. Expand
Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation
TLDR
It is found that the lipolytic enzyme, ATGL is highly expressed in human HCC tissues and predicts poor prognosis, and high levels of DAG and FFA are present in H CC tissues. Expand
Overexpression of candidate tumor suppressor ECRG4 inhibits glioma proliferation and invasion
TLDR
The data suggest that ECRG4 serves as a tumor suppressor in glioma, inversely correlated with nuclear transcription factor NF-kB levels. Expand
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