• Publications
  • Influence
Synthesis and evaluation of water-soluble docetaxel prodrugs-docetaxel esters of malic acid.
TLDR
2'-dl-Malyl docetaxel sodium salt demonstrated enhanced antitumor activity in vitro when compared to docetAXel and showed the inhibitory effect on tumor growth in vivo. Expand
Tumor hypoxia enhances non-small cell lung cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling
TLDR
The results suggest that intermittent hypoxia significantly promotes the metastasis of Lewis lung carcinoma (LLC), accompanied with more CD209+ macrophages infiltrated in primary tumor tissue, andHypoxia and IL-6 cooperate to enhance the LLC metastasis both in vitro and in vivo. Expand
Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin.
TLDR
Findings indicate that puerarin protects the myocardium against ischemia and reperfusion injury via opening the calcium-activated potassium channel and activating protein kinase C. Expand
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.
TLDR
A new series of flavonoid derivatives have been designed, synthesized and evaluated and showed more potent inhibitory activities to AChE than rivastigmine, showing high BChE/AChE inhibition ratio and superior to donepezil. Expand
Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy
TLDR
The roles and mechanisms of USPs in malignant transformation and progression as well as recent advances of small-molecule inhibitors targeting USPs are summarized. Expand
Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.
TLDR
The data suggested that the JNK-Bcl-2 pathway was considered as the critical regulator of CA-4-induced protective autophagy and a potential drug target for chemotherapeutic combination. Expand
VEGF and Bcl-2 Interact Via MAPKs Signaling Pathway in the Response to Hypoxia in Neuroblastoma
TLDR
Evidence shows that vascular endothelial growth factor (VEGF) stimulates angiogenesis in tumor growth and mediates neuroprotection to prevent an apoptotic cell death and suggests a strategy based on the blockade of hypoxia-induced VEGF signaling under hypoxic treatment in neuroblastoma. Expand
Effects of Vegetarian Diets on Blood Lipids: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
TLDR
Evidence is provided that vegetarian diets effectively lower blood concentrations of total cholesterol, low‐density lipoprotein cholesterol, high‐ density lipop Protein cholesterol, and non–high‐density cholesterol cholesterol, which could be a useful nonpharmaceutical means of managing dyslipidemia, especially hypercholesterolemia. Expand
DJ-1 as a human oncogene and potential therapeutic target.
TLDR
The role of DJ-1 in transformation is discussed, some of the significant aspects of and prospects for therapeutically targeting theDJ-1 signaling in cancer are highlighted, and what the future may hold are described. Expand
All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages
TLDR
M2 macrophages enhanced metastasis of K7M2 WT osteosarcoma cells to the lungs in mice, thus establishing M2 TAMs as a therapeutic target for blocking osteosARcoma metastasis and identifying ATRA as a possible antimetastasis therapeutic. Expand
...
1
2
3
4
5
...