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Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines
Identification of TLR2 and TLR4-induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals
The present study aimed to identify the global expression change of miRNAs in BM-MSCs stimulated with LPS and PM, providing the opportunity to further elucidate the roles of mi RNAs in mediating TLR signals to regulate the functions of BM- MSCs.
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer
The findings suggest that miR-4306 acts as a tumor suppressor in TNBC and is a potential therapeutic target for TNBC treatment.
Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon- stimulated gene factor 3
It is concluded that a defect in activation of ISGF3 is a possible cause for resistance in CLL cells to IFN-induced blast transformation in vitro.
Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
- XiaoHu Sun, Xinzhong Chang, Yunhua Wang, Bo Xu, Xuchen Cao
- Biology, ChemistryBioMed research international
- 23 June 2019
It is suggested that Oroxylin A inhibited the cell proliferation, invasion, migration, and EMT through inactivating NF-κB signaling pathway in human breast cancer cells and could be a therapeutic potential candidate for the treatment of breast cancer.
Cisplatin-Resistant Gastric Cancer Cells Promote the Chemoresistance of Cisplatin-Sensitive Cells via the Exosomal RPS3-Mediated PI3K-Akt-Cofilin-1 Signaling Axis
- Meng-Yao Sun, Bo Xu, Qing-Feng Tang
- Biology, ChemistryFrontiers in Cell and Developmental Biology
- 21 July 2020
It was demonstrated that exosomal RPS3 was essential for inducing chemoresistance of receptor cells as shown by the acquisition of this phenotype in SGC7901S cells with enforced expression of Rps3, and Targeting exosome R PS3 protein in cisplatin-resistant gastric cancer cells may be a promising strategy to overcome cisplin resistance.
[Effects of sorafenib on proliferation and apoptosis of human multiple myeloma cell RPMI 8226].
- N. Zhou, Bao-Lan Liu, M. Qi, Bo Xu, Xin Liu
- Biology, ChemistryZhongguo shi yan xue ye xue za zhi
- 1 April 2010
It is concluded that sorafenib displays anti-myeloma activity, Activating the death receptor pathway and arresting cell cycle may be two of the relatated mechanisms.
TET2 Inhibits PD-L1 Gene Expression in Breast Cancer Cells through Histone Deacetylation
The work reveals an unanticipated role of TET2-HDAC1/2 complex in the regulation of PD-L1 gene expression, providing new insights into the epigenetic mechanisms that drive immune evasion during breast cancer pathogenesis.
A novel small molecule that induces oxidative stress and selectively kills malignant cells.
[Proteasome inhibitor induces apoptosis and influences the expression of Notch1 and NF-kappaB in multiple myeloma RPMI8226 cells].
It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF -kappa B signaling pathways, indicating that notch 1 signal may be a latent target in treating MM.