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Leptin-induced transactivation of NPY gene promoter mediated by JAK1, JAK2 and STAT3 in the neural cell lines
Results indicated that activation of JAK1, JAK2 and STAT3 is necessary for leptin-induced transactivation of NPY gene through the leptin-response element in these neural cells. Expand
Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer
The findings suggest that miR-4306 acts as a tumor suppressor in TNBC and is a potential therapeutic target for TNBC treatment. Expand
Identification of TLR2 and TLR4-induced microRNAs in human mesenchymal stem cells and their possible roles in regulating TLR signals
The present study aimed to identify the global expression change of miRNAs in BM-MSCs stimulated with LPS and PM, providing the opportunity to further elucidate the roles of mi RNAs in mediating TLR signals to regulate the functions of BM- MSCs. Expand
Primary leukemia cells resistant to alpha-interferon in vitro are defective in the activation of the DNA-binding factor interferon- stimulated gene factor 3
It is concluded that a defect in activation of ISGF3 is a possible cause for resistance in CLL cells to IFN-induced blast transformation in vitro. Expand
Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells
It is suggested that Oroxylin A inhibited the cell proliferation, invasion, migration, and EMT through inactivating NF-κB signaling pathway in human breast cancer cells and could be a therapeutic potential candidate for the treatment of breast cancer. Expand
[Effects of sorafenib on proliferation and apoptosis of human multiple myeloma cell RPMI 8226].
It is concluded that sorafenib displays anti-myeloma activity, Activating the death receptor pathway and arresting cell cycle may be two of the relatated mechanisms. Expand
[Proteasome inhibitor induces apoptosis and influences the expression of Notch1 and NF-kappaB in multiple myeloma RPMI8226 cells].
It is concluded that Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis and there may be some correlation between the Notch 1 and NF -kappa B signaling pathways, indicating that notch 1 signal may be a latent target in treating MM. Expand
A novel small molecule that induces oxidative stress and selectively kills malignant cells.
XB05 is a novel compound that selectively kills malignant cells, most likely by disrupting cellular redox homeostasis, making it a promising candidate for development as a chemotherapeutic agent. Expand
Cisplatin-Resistant Gastric Cancer Cells Promote the Chemoresistance of Cisplatin-Sensitive Cells via the Exosomal RPS3-Mediated PI3K-Akt-Cofilin-1 Signaling Axis
It was demonstrated that exosomal RPS3 was essential for inducing chemoresistance of receptor cells as shown by the acquisition of this phenotype in SGC7901S cells with enforced expression of Rps3, and Targeting exosome R PS3 protein in cisplatin-resistant gastric cancer cells may be a promising strategy to overcome cisplin resistance. Expand
MicroRNA‑155 targets myosin light chain kinase to inhibit the migration of human bone marrow‑derived mesenchymal stem cells.
  • X. Wang, X. Ye, +5 authors Xin Liu
  • Chemistry, Medicine
  • International journal of molecular medicine
  • 1 September 2018
The results may facilitate the development and clinical use of BM‑MSCs in terms of their migration and microRNAs involved in various biological functions by mediating mRNA degradation or inhibiting the translation of target genes. Expand