Bo Wang

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A human gut microbial gene catalogue established by metagenomic sequencing

Junjie Jia Guowei Qin, Jeroen Raes, +49 authors Jun Wang
Nature
2010

To understand the impact of gut microbes on human health and well-being it is crucial to assess their genetic potential. Here we describe the Illumina-based metagenomic sequencing, assembly and… (More)

Bo Wang, Aziz M. Mezlini, +5 authors Anna Goldenberg
Nature Methods
2014

Recent technologies have made it cost-effective to collect diverse types of genome-wide data. Computational methods are needed to combine these data to create a comprehensive view of a given disease… (More)

The draft genome of a diploid cotton Gossypium raimondii

Kunbo Wang, Zhiwen Wang, +26 authors Shuxun Yu
Nature Genetics
2012

We have sequenced and assembled a draft genome of G. raimondii, whose progenitor is the putative contributor of the D subgenome to the economically important fiber-producing cotton species Gossypium… (More)

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.

Shu-hao Hsu, Bo Wang, +15 authors Kalpana Ghoshal
The Journal of clinical investigation
2012

miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in hepatocellular carcinoma (HCC)… (More)

A heterozygous moth genome provides insights into herbivory and detoxification

Minsheng You, Zhen Yue, +50 authors Jun Wang
Nature Genetics
2013

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically… (More)

Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice.

Bo Wang, Sarmila Majumder, +7 authors S. T. Jacob
Hepatology
2009

UNLABELLED MicroRNAs (miRs) are conserved, small (20-25 nucleotide) noncoding RNAs that negatively regulate expression of messenger RNAs (mRNAs) at the posttranscriptional level. Aberrant expression… (More)

TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3

Bo Wang, Shu-hao Hsu, +4 authors Kalpana Ghoshal
Oncogene
2010

To identify microRNAs (miRNAs) that may have a causal role in hepatocarcinogenesis, we used an animal model in which C57BL/6 mice fed choline-deficient and amino acid defined (CDAA) diet develop… (More)

TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4.

Catherine E. Winbanks, Bo Wang, +4 authors Paul Gregorevic
The Journal of biological chemistry
2011

MicroRNAs (miRs) are emerging as prominent players in the regulation of many biological processes, including myogenic commitment and skeletal muscle formation. Members of the TGF-β family can… (More)

Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants

A Leslie Morrow, Anne J. Lagomarcino, +10 authors David S Newburg
Microbiome
2013

BACKGROUND Necrotizing enterocolitis (NEC) is a devastating intestinal disease that afflicts 10% of extremely preterm infants. The contribution of early intestinal colonization to NEC onset is not… (More)

Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis.

Bo Wang, Radko Komers, +9 authors Phillip Kantharidis
Journal of the American Society of Nephrology…
2012

Synthesis and deposition of extracellular matrix (ECM) within the glomerulus and interstitium characterizes renal fibrosis, but the mechanisms underlying this process are incompletely understood. The… (More)

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