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Model-based analysis of ChIP-seq (MACS) is a computational algorithm that identifies genome-wide locations of transcription/chromatin factor binding or histone modification from ChIP-seq data. MACS consists of four steps: removing redundant reads, adjusting read position, calculating peak enrichment and estimating the empirical false discovery rate (FDR).(More)
A group key agreement (GKA) protocol allows a set of users to establish a common secret via open networks. Observing that a major goal of GKAs for most applications is to establish a confidential channel among group members, we revisit the group key agreement definition and distinguish the conventional (symmetric) group key agreement from asymmetric group(More)
The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite the importance of HIF1A in homeostasis and various pathologies, little is known about how it regulates RNA polymerase II (RNAPII). We report here that HIF1A employs a specific variant of the Mediator complex to stimulate RNAPII elongation. The Mediator-associated(More)
In 2010, Fan et al. presented an anonymous multi-receiver identity-based encryption scheme where they adopt Lagrange interpolating polynomial mechanism. They showed that their scheme makes it impossible for an attacker or any other message receiver to derive the identity of a message receiver such that the privacy of every receiver can be guaranteed. They(More)
AIMS To explore the association of microbial community structure with the development of eutrophication in a large shallow freshwater lake, Lake Taihu. METHODS AND RESULTS The bacterial and archaeal assemblages in sediments of different lake areas were analysed using denaturing gradient gel electrophoresis (DGGE) of amplified 16S rDNA fragments. The(More)
Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of(More)
Human enterovirus 71 (EV71) is the major pathogen that causes hand, foot and mouth disease that particularly affects young children. Growing hand, foot and mouth disease outbreaks were observed worldwide in recent years and caused devastating losses both economically and politically. However, vaccines or effective drugs are unavailable to date. The genome(More)
CYP51 sterol demethylases are the only cytochrome P450 enzymes with a conserved function across the animal, fungal, and plant kingdoms (in the synthesis of essential sterols). These highly conserved enzymes, which are important targets for cholesterol-lowering drugs, antifungal agents, and herbicides, are regarded as the most ancient member cytochrome P450(More)