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BACKGROUND The genes boule and dazl are members of the DAZ (Deleted in Azoospermia) family encoding RNA binding proteins essential for germ cell development. Although dazl exhibits bisexual expression in mitotic and meiotic germ cells in diverse animals, boule shows unisexual meiotic expression in invertebrates and mammals but a bisexual mitotic and meiotic(More)
Recent genome-wide association studies indicate that a simple alteration of Leucine-rich repeat kinase 2 (LRRK2) gene expression may contribute to the etiology of sporadic Parkinson's disease (PD). However, the expression and regulation of LRRK2 protein in the sporadic PD brains remain to be determined. Here, we found that the expression of LRRK2 protein(More)
Doxorubicin (Dox) is an anthracycline antibiotic for cancer therapy with limited usage due to cardiotoxicity. Isorhamnetin is a nature antioxidant with obvious cardiac protective effect. The aim of this study is going to investigate the possible protective effect of isorhamnetin against Dox-induced cardiotoxicity and its underlying mechanisms. In an in vivo(More)
Visual contour tracking in complex background is a difficult task. The measurement model is often nonlinear due to clutter in images. Traditional visual tracker based on Kalman filter employs simple linear measurement model, and often collapses in tracking process. The paper presents a new contour tracker based on Unscented Kal-man filter that is superior(More)
Leucine-rich repeat kinase 2 (LRRK2) has been associated with Parkinson's disease (PD) and other disorders. However, its normal physiological functions and pathogenic properties remain elusive. Here we show that LRRK2 regulates the anterograde ER-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES). LRRK2 interacted and(More)
Advances in diagnosis and treatment have rendered most solid tumors largely curable if they are diagnosed and treated before dissemination. However, once they spread beyond the initial primary location, these cancers are usually highly morbid, if not fatal. Thus, current efforts focus on both limiting initial dissemination and preventing secondary spread.(More)
One of the main limitations of intracerebral hemorrhage (ICH) research is lack of reproducible animal models. ICH appears to be associated with a volume of edema and ischemic injury surrounding the hematoma that may be reduced by nimodipine due to its vasodilating and cytoprotective effects. The present study was designed to produce a modified ICH model in(More)
Contour tracking can be implemented by measuring the probability distributions (e.g. intensity, color and texture) of both interior and exterior regions of an object contour. Choosing a suitable distance metric for measuring the (dis)similarity between two distributions significantly influences the tracking performance. Most existing contour tracking(More)