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- A. Mathew Thomas, Steven N. Hart, Bo Kong, Jianwen Fang, Xiao-bo Zhong, Grace L. Guo
- Hepatology
- 2010
UNLABELLED
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor belonging to the nuclear receptor superfamily. FXR is highly expressed in liver and intestine and crosstalk… (More)
- Bo Kong, Li Wang, John Y. L. Chiang, Youcai Zhang, Curtis D. Klaassen, Grace L. Guo
- Hepatology
- 2012
UNLABELLED
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile-acid synthesis by reducing the expression levels of genes encoding key bile-acid synthetic enzymes… (More)
- Stefan Eser, Nina Reiff, +19 authors Dieter Saur
- Cancer cell
- 2013
Oncogenic Kras activates a plethora of signaling pathways, but our understanding of critical Ras effectors is still very limited. We show that cell-autonomous phosphoinositide 3-kinase (PI3K) and… (More)
- Yuxia Zhang, Ningyi Xu, +4 authors Li Wang
- Hepatology
- 2014
UNLABELLED
E2F transcription factor 1 (E2F1) is an important regulator of metabolic diseases; however, its role in liver function remains elusive. This study unraveled a regulatory cascade involving… (More)
- Bo Kong, James P. Luyendyk, Ossama Tawfik, Grace L. Guo
- The Journal of pharmacology and experimental…
- 2009
Nonalcoholic steatohepatitis (NASH) comprises dysregulation of lipid metabolism and inflammation. Identification of the various genetic and environmental susceptibility factors for NASH may provide… (More)
- Sören Müller, Susanne Raulefs, +16 authors Christoph W. Michalski
- Molecular Cancer
- 2015
Previous studies identified microRNAs (miRNAs) and messenger RNAs with significantly different expression between normal pancreas and pancreatic cancer (PDAC) tissues. Due to technological… (More)
- Xiaohua Jiang, Ivane Abiatari, +6 authors Joerg Kleeff
- Pancreatology : official journal of the…
- 2009
AIMS
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticins have been identified as tissue-specific angiogenic factors. This study investigates the expression and… (More)
- Bo Kong, Weiwei Wu, +19 authors Christoph W. Michalski
- Gut
- 2016
OBJECTIVE
Oncogenic Kras-activated robust Mek/Erk signals phosphorylate to the tuberous sclerosis complex (Tsc) and deactivates mammalian target of rapamycin (mTOR) suppression in pancreatic ductal… (More)
- Shuqing Zhang, Xiaodong Na, +6 authors Patricia Dale
- Wetlands
- 2009
Maximum likelihood supervised classification and post-classification change detection techniques were applied to Landsat MSS/TM images acquired in 1976, 1986, 1995, 2000, and 2005 to map land cover… (More)
- Mert Erkan, Carolin Reiser-Erkan, +4 authors Joerg Kleeff
- Current molecular medicine
- 2012
Around 95% of patients diagnosed with pancreatic cancer will die of their disease within 5 years, three quarters within a year. The major hurdle in improving prognosis is the lack of a therapeutic… (More)