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BACKGROUND The influence of changes in heart rate on myocardial contractility (the force-frequency effect) differs under various experimental conditions, including the anesthetized versus the conscious state. METHODS AND RESULTS To assess the influence of beta-adrenergic stimulation on force-frequency effects on myocardial contraction and relaxation,(More)
BACKGROUND The potential role of myocardial cell hypertrophy in the ischemic zone in the mechanism of late recovery of regional contractile function after myocardial infarction followed by reperfusion has not been examined. METHODS AND RESULTS Eight chronically instrumented, conscious dogs were subjected to 90-120 minutes of circumflex coronary artery(More)
BACKGROUND beta-Adrenergic blockade is known to improve the survival of patients after acute myocardial infarction and to reduce myocardial infarct size in experimental coronary occlusion. However, the effects of beta-blockade on global and regional left ventricular (LV) remodeling have not been characterized after coronary occlusion with reperfusion. In(More)
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