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PURPOSE To estimate the prevalence of dry eye disease, analyze the associations between dry eye symptoms and signs, and identify the risk factors in an elderly Mongolian population at high altitude in China. METHODS A population-based survey was conducted in 2006. A total of 2,486 Mongolians age 40 and older were selected. Symptoms of dry eye were(More)
DNA has the theoretical capability of storing vast databases in a very compact volume, for example, a gram of DNA can store 4.2 x 10 21 bits of information. Subsequently, encoded data can be retrieved by associative search queries. However, until now no large scale experiments have verified this. We describe the experimental creation of very large databases(More)
2 DNA is a crucial construction material for molecular scale objects with nano-scale features. Diverse synthetic DNA objects hold great potential for applications such as nano-fabrication, nano-robotics, nano-computing, and nano-electronics. The construction of DNA objects is generally carried out via self-assembly. During self-assembly, DNA strands are(More)
  • Bo Guo, Liying Liu, +5 authors Chen Huang
  • 2014
UNLABELLED Results from recent studies suggest that aberrant microRNA expression is common in numerous cancers. Although miR-338-3p has been implicated in hepatocellular carcinoma, its role in gastric cancer is unknown. To this end, we report that miR-338-3p is downregulated in both gastric cancer tissue and cell lines. Forced expression of miR-338-3p(More)
This study aimed to detect potential serum biomarkers for gastric cancer. In the present study, we used magnetic bead-based purification and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry to detect potential serum markers in 70 gastric cancer (GC) patients compared with 72 healthy controls. On average, up to 81(More)
PURPOSE We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber layer (RNFL) thickness was measured by(More)
Although the critical role of complement component C3d as a molecular adjuvant in preventing virus infection is well established, its role in cancer therapies is unclear. In this study, we have engineered a DNA vaccine that expresses extracellular region of murine VEGFR-2 (FLK1(265-2493)) and 3 copies of C3d (C3d3), a component of complement as a molecular(More)
Aberrant DNA methylation is one of the main drivers of tumor initiation and progression. The reversibility of methylation modulation makes it an attractive target for novel anticancer therapies. Clinical studies have demonstrated that high-dose decitabine, a hypomethylating agent, results in some clinical benefits in patients with refractory advanced(More)