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The ongoing enhancement of mobile devices capabilities and advanced technologies has largely contributed to the huge increase of wireless traffic demand. Mobile network operators around the world are struggling to manage this new era of higher generation networks by finding new means and strategies to implement in order to meet the explosion in traffic(More)
Inspired by biological communication, the strategy of deploying communication and storage equipment called thrown box is proposed to increase message delivery probability and to reduce transmission latency in delay tolerant networks. In this paper, we study the thrown-box assisted message dissemination models by analyzing a few cases on the message delivery(More)
The proteins involved in breast cancer initiation and progression are still largely elusive. To gain insights into these processes, we conducted quantitative proteomic analyses with 21T series of breast cell lines, which include a normal, primary tumor and a metastatic tumor that were isolated from a single patient. Stable isotope labeling of amino acid in(More)
Several lines of evidence suggest that the human 5-HT(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. A pharmocogenetics study of this receptor may therefore be useful in developing individualized therapy. But few studies about it have been done. In this study, we genotyped ten single(More)
In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 also regulates gluconeogenesis is less clear. Here, we report that p53 efficiently down-regulates the expression of phosphoenolpyruvate carboxykinase (PCK1) and(More)
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered. It has a wide range of functions covering cell cycle control, apoptosis, genome integrity maintenance, metabolism, fertility, cellular reprogramming and autophagy. Although different possible underlying mechanisms for p53 regulation have been proposed for decades, none(More)