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Increased concentrations of DNA-containing immune complexes in the serum are associated with systemic autoimmune diseases such as lupus. Stimulation of Toll-like receptor 9 (TLR9) by DNA is important in the activation of plasmacytoid dendritic cells and B cells. Here we show that HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an(More)
Inspired by the great success of information retrieval (IR) style keyword search on the web, keyword search on XML has emerged recently. The difference between text database and XML database results in three new challenges: (1) Identify the user search intention, i.e. identify the XML node types that user wants to search for and search via. (2) Resolve(More)
Efficient targeting of proteins for degradation from the secretory pathway is essential to homeostasis. This occurs through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we establish that a human ubiquitin ligase (E3), gp78, and a specific E2, Ube2g2, are both critically important for ERAD of multiple substrates. gp78 exhibits a(More)
Recent research has seen the proposal of several new inductive principles designed specifically to avoid the problems associated with maximum likelihood learning in models with intractable partition functions. In this paper, we study learning methods for binary restricted Boltzmann machines (RBMs) based on ratio matching and generalized score matching. We(More)
Remote Data Checking (RDC) is a technique by which clients can establish that data outsourced at untrusted servers remains intact over time. RDC is useful as a <i>prevention</i> tool, allowing clients to periodically check if data has been damaged, and as a <i>repair</i> tool whenever damage has been detected. Initially proposed in the context of a single(More)
Retroviral capsid proteins are conserved structurally but assemble into different morphologies. The mature human immunodeficiency virus-1 (HIV-1) capsid is best described by a 'fullerene cone' model, in which hexamers of the capsid protein are linked to form a hexagonal surface lattice that is closed by incorporating 12 capsid-protein pentamers. HIV-1(More)
One common predictive modeling challenge occurs in text mining problems is that the training data and the operational (testing) data are drawn from different underlying distributions. This poses a great difficulty for many statistical learning methods. However, when the distribution in the source domain and the target domain are not identical but related,(More)
We present a class of efficient models called MobileNets for mobile and embedded vision applications. MobileNets are based on a streamlined architecture that uses depthwise separable convolutions to build light weight deep neural networks. We introduce two simple global hyperparameters that efficiently trade off between latency and accuracy. These(More)
Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with oesophageal squamous cell carcinoma (ESCC) being the histopathological form in the vast majority of cases (>90%). Currently, there are limited clinical approaches for the(More)
Oxidative stress plays an important role in Alzheimer's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L, shows potent antioxidant property. In this paper, the neuroprotective effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis in SH-SY5Y cells were investigated.(More)