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BACKGROUND We evaluated KRAS (mKRAS (mutant KRAS)) and BRAF (mBRAF (mutant BRAF)) mutations to determine their prognostic potential in assessing patients with colorectal cancer (CRC) for lung metastasectomy. METHODS Data were reviewed from 180 patients with a diagnosis of CRC who underwent a lung metastasectomy between January 1998 and December 2011. (More)
Today's follow-up of patients presenting abdominal tumors is generally performed through acquisition of dynamic sequences of contrast-enhanced CT. Estimating parameters of appropriate models of contrast intake diffusion through tissues should help characterizing the tumor physiology, but is impeded by the high level of noise inherent to the acquisition(More)
Patients follow-up in oncology is generally performed through the acquisition of dynamic sequences of contrast-enhanced images. Estimating parameters of appropriate models of contrast intake diffusion through tissues should help characterizing the tumour physiology. However, several models have been developed and no consensus exists on their clinical use.(More)
Dynamic contrast-enhanced computed tomography (DCE-CT) is a valuable imaging modality to assess tissues properties, particularly in tumours, by estimating pharmacokinetic parameters from the evolution of pixels intensities in 3D+t acquisitions. However, this requires a registration of the whole sequence of volumes, which is challenging especially when the(More)
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