Blanche A. Simpson

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Central nervous system infections involving vancomycin-resistant Enterococcus faecium (VREF) are infrequently described and pose significant therapeutic difficulties, because these organisms are intrinsically resistant to many antibiotics. We describe the use of intrathecal quinupristin/dalfopristin to treat a VREF-associated infection in a neuro--surgical(More)
Cutaneous basophil hypersensitivity (CBH) is a distinct form of lymphocyte-mediated hypersensitivity in guinea pigs, separate both from classic delayed hypersensitivity (DH) and from the well-known antibody-mediated reactions. CBH, not DH, is the usual cellular immune response of this species to a wide variety of immunogens (e.g., allografts, certain(More)
Neurosurgical treatment for psychiatric disorders has a long and controversial history dating back to antiquity. Both enthusiastic reports and social outcry have accompanied psychosurgical practice, particularly over the last century. Frontal lobotomy has probably been the only medical advance which was first awarded a Nobel prize in medicine and then(More)
Operative neuromodulation is the field of altering electrically or chemically the signal transmission in the nervous system by implanted devices in order to excite, inhibit or tune the activities of neurons or neural networks and produce therapeutic effects. It is a rapidly evolving biomedical and high-technology field on the cutting-edge of developments(More)
Operative Neuromodulation is the field of altering electrically or chemically the signal transmission in the nervous system by implanted devices in order to excite, inhibit or tune the activities of neurons or neural networks and produce therapeutic effects. The present article reviews relevant literature on procedures or devices applied either in contact(More)
Modification of the cellular immune response by sensitization with adjuvants containing tubercle bacilli has been carefully studied in whole animals of several species (1-5). Guinea pigs immunized with a foreign protein in Freund's complete adjuvant (CFA) 1 develop persistent delayed hypersensitivity with an erythematous skin test response that is delayed(More)
BY HAROLD F. DVORAK,§ M.D., ANN M. DVORAK,I 1 M.D., BLANCHE A. SIMPSON, HAL B. RICHERSON, M.D., SIDNEY LESKOWITZ, PH.D., Asm MORRIS J. KARNOVSKY, M.B.B.Cm (From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, and the Departments of Medicine and Bacteriology and Immunology, Massachusetts General Hospital and Harvard(More)
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