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Reviewers The Publications Committee of the American Physiological Society gratefully acknowledges the services of the following reviewers who assisted the Editorial Board in the reviews of manuscripts. I would like to recommend that our library subscribe to the American Journal of Physiology–Cell Physiology. This is a journal published online and in print(More)
Rapid-response impulsivity, characterized by inability to withhold response to a stimulus until it is adequately appraised, is associated with risky behavior and may be increased in a state-dependent manner by norepinephrine. We assessed effects of yohimbine, which increases norepinephrine release by blocking alpha-2 noradrenergic receptors, on plasma(More)
The effect of a series of indoleamines on the potassium-evoked tritium release of previously accumulated [3H]dopamine from rat striatal slices has been investigated. The indoleamines 5-hydroxytryptamine, 5-methoxytryptamine, 5-methoxy-N,N'-dimethyltryptamine and tryptamine (10(-7) to 10(-5) M) all reduced potassium-evoked release of tritium, to a maximum of(More)
1. Intrahypothalamic injection of either dopamine or noradrenaline in a dose volume of 1 mul. caused a fall in core temperature in lightly restrained rats maintained at an ambient temperature of 17 +/- 1 degrees C.2. The hypothermic effects of dopamine (10 mug) and noradrenaline (2 mug) were selectively antagonized by systemic pre-treatment with pimozide(More)
Early responses to stimuli can be measured by sensory evoked potentials (EP) using repeated identical stimuli, S1 and S2. Response to S1 may represent efficient stimulus detection, while suppression of response to S2 may represent inhibition. Early responses to stimuli may be related to impulsivity. We compared EP reflecting stimulus detection and(More)
Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a Y1 receptor selective antagonist, we examined this hypothesis in the isolated and perfused mesenteric vascular bed. SNS(More)
The effects of the novel, highly selective serotonin-2 (5-HT2) antagonists, ICI 169,369 and ICI 170,809, on 24 h EEG sleep-wake activity were studied in the rat. Both compounds caused a dose-related increase in the latency to rapid eye movement sleep (REMS) and significantly suppressed cumulative REMS time up to 12 h postinjection. In contrast, neither drug(More)