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Whereas genomic data are universally machine-readable, data from imaging, multiplex biochemistry, flow cytometry and other cell- and tissue-based assays usually reside in loosely organized files of… (More)
MOTIVATION Linking experimental data to mathematical models in biology is impeded by the lack of suitable software to manage and transform data. Model calibration would be facilitated and models… (More)
Epithelial cells respond to growth factors including epidermal growth factor (EGF), insulin-like growth factor 1 (IGF-1), and insulin. Using high-content immunofluorescence microscopy, we quantitated… (More)
Osteoclasts are responsible for bone destruction in degenerative, inflammatory and metastatic bone disorders. Although osteoclastogenesis has been well-characterized in mouse models, many questions… (More)
Introduction/Hypothesis: After AMI, patients suffer irreversible loss of heart function due to cardiomyocyte (CM) death and tissue scarring that may lead to heart failure. Growth factors can reduce...
In pursuit of greater understanding of structure property relationships in NLO chromophores, a series of molecules consisting of three aromatic rings was synthesized. The relative positions of… (More)
Proliferation of mammary epithelial cells is stimulated by epidermal growth factor (EGF), but not by insulin-like growth factor 1 (IGF-1) or insulin. To understand the signaling mechanisms underlying… (More)