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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
Summary Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic controlExpand
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The immune epitope database (IEDB) 3.0
TLDR
The IEDB, www.iedb.org, contains information on immune epitopes—the molecular targets of adaptive immune responses—curated from the published literature and submitted by National Institutes of Health funded epitope discovery efforts. Expand
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The Immune Epitope Database 2.0
TLDR
The Immune Epitope Database (IEDB, www.iedb.org) provides a catalog of experimentally characterized B and T cell epitopes, as well as data on Major Histocompatibility Complex (MHC) binding and MHC ligand elution experiments. Expand
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ElliPro: a new structure-based tool for the prediction of antibody epitopes
TLDR
We present ElliPro, a web-tool that implements Thornton's method and, together with a residue clustering algorithm, the MODELLER program and the Jmol viewer, allows the prediction and visualization of antibody epitopes in a protein sequence or structure. Expand
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Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method
TLDR
We report the implementation of the Stabilized Matrix Method (SMM) algorithm as a publicly available software package. Expand
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A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2
Summary Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools to understand and monitorExpand
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NetMHCpan, a method for MHC class I binding prediction beyond humans
Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic regionExpand
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The Immune Epitope Database (IEDB): 2018 update
TLDR
The Immune Epitope Database (IEDB) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. Expand
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NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data
Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC class I molecules.Expand
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A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach
TLDR
The identification of MHC class II restricted peptide epitopes is an important goal in immunological research. Expand
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