Bjørn Bratland

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In a double-blind double-dummy multicenter study, patients with mild to moderate essential hypertension were randomized to receive either nifedipine (n = 416, 47.6% women) or lisinopril (n = 412, 50% women), and side effects were registered by specific questioning, by spontaneous reports, and by use of visual analog scales. Cough was spontaneously reported(More)
In a randomized, parallel, double-blind study, lisinopril (n = 412; average dose 18.8 mg) reduced systolic and diastolic blood pressure (change = 20.2/13.8 mmHg; P less than 0.01/P less than 0.01) more than nifedipine (n = 416; average dose 37.4 mg; change = 13.3/11.2 mmHg) after 10-week treatment in patients, aged 40-70 years, with mild-to-moderate(More)
BACKGROUND Warfarin treatment gives a well-documented reduction of the risk of thrombosis, but makes the patients more liable to bleedings. In Norway most patients are treated in general practice. MATERIAL AND METHODS This study describes a 16-year-material (1988-2003) of 427 patients on warfarin in a practice with five general practitioners, based on(More)
Single cardiovascular risk factor intervention is probably not sufficient to prevent atherosclerosis progression. There is a lack of data on concomitant use of hypocholesterolemic agents and antihypertensive drugs with respect to possible interactions and adverse experiences. We studied 293 patients (below 65 years of age) under treatment with either(More)
In a randomized, double blind, parallel-group, multicentre study in Norway, 97 patients with mild to moderate hypertension (mean blood pressure 159/104 mm Hg) were treated with either lisinopril 10-40 mg or nifedipine 20-80 mg and the effects on blood lipids were evaluated. Complete results of laboratory analyses are given for 80 patients. After a 4 week(More)
In a randomized, parallel, double-blind study, lisinopril (n = 412) reduced systolic and diastolic blood pressure more than nifedipine did (n = 416) after ten weeks treatment in patients (40-70 years) with mild to moderate essential hypertension. Lisinopril was tolerated better than nifedipine, with fewer withdrawals. Adverse experiences reported after a(More)
BACKGROUND Atrial fibrillation increases by fivefold the risk for thromboembolic stroke. Warfarin therapy reduces that risk by 64%, but increases the risk for major bleeding. We wanted to study the quality of the warfarin therapy given in a Norwegian general practice and to calculate which patients would have probable benefit of the treatment. MATERIAL(More)
There is much discussion about the use of the new antidepressant drugs. Some advocate a more liberal use while others criticize overprescribing. Our study examines the indication, dosage and length of treatment in five family practices. Records of 208 patients prescribed one of three new antidepressants in 1995 were reviewed. 90% had depression or anxiety(More)