Björn Steffen

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Development of distant metastasis after tumor resection is the leading cause of death in early-stage non-small cell lung cancer (NSCLC). Receptor tyrosine kinases (RTK) are involved in tumorigenesis but only few RTKs have been systematically studied in NSCLC. Here, we provide quantitative real-time reverse transcription-PCR expression data of all RTKs(More)
Distant metastasis is the predominant cause of death in early-stage non-small cell lung cancer (NSCLC). Currently, it is impossible to predict the occurrence of metastasis at early stages and thereby separate patients who could be cured by surgical resection alone from patients who would benefit from additional chemotherapy. In this study, we applied a(More)
Novel high-throughput analyses in molecular biology allow sensitive and rapid identification of disease-related genes and drug targets. We have used quantitative real-time reverse transcription-PCR reactions (n = 23000) to analyze expression of all human receptor tyrosine kinases (n = 56) in malignant tumors (n = 313) of different origins and normal control(More)
Activating Flt3 mutations occur in about 30% of patients with acute myeloid leukemia (AML), often as in-frame internal tandem duplication (ITD) at the juxtamembrane domain of the receptor. These mutations transform hematopoietic cell lines and primary mouse bone marrow. Here, we analyzed the interaction between oncogenic Flt3-ITD mutations and the(More)
In the disjoint path allocation problem, we consider a path of L + 1 vertices, representing the nodes in a communication network. Requests for an unbounded-time communication between pairs of vertices arrive in an online fashion and some central authority has to decide which of these calls to admit. The constraint is that each edge in the path can serve(More)
In this paper, we deal with several reoptimization variants of the Steiner tree problem in graphs obeying a sharpened β-triangle inequality. A reoptimization algorithm exploits the knowledge of an optimal solution to a problem instance for finding good solutions for a locally modified instance. We show that, in graphs satisfying a sharpened triangle(More)
In acute myeloid leukemia (AML), receptor tyrosine kinase ligands promote growth and survival and contribute to AML-associated marrow neoangiogenesis. We have tested simultaneous inhibition of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor receptor signaling by novel indolinone derivatives using 14 myeloid,(More)
In this paper, we aim to do more than arguing that infor-matics is a fascinating scientific discipline with interesting applications in almost all areas of everyday life. We pose the following questions: What are the educational requirements demanded from school subjects? Can we answer this question as satisfactory as we can do it, for instance, for(More)