Björn Högberg

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In rolling circle replication, a circular template of DNA is replicated as a long single-stranded DNA concatamer that spools off when a strand displacing polymerase traverses the circular template. The current view is that this type of replication can only produce single-stranded DNA, because the only 3'-ends available are the ones being replicated along(More)
We have developed a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures [Douglas, Dietz, et al. 2009]. Previously, scaffolded DNA origami has been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome [Rothemund 2006]. Now we have(More)
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