—Sensor arrays are a key tool in the field of neuro-science for noninvasive recording of the activity of biological networks , such as dissociated neurons or neural tissue. A high-density sensor array complementary metal–oxide–semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 m 7.8 m for imaging of… (More)
resolution multitransistor array recording of electrical field potentials in cultured brain slices. We report on the recording of electrical activity in cultured hippocampal slices by a multitransistor array (MTA) with 16,384 elements. Time-resolved imaging is achieved with a resolution of 7.8 m on an area of 1 mm 2 at 2 kHz. A read-out of fewer elements… (More)
We report on the recording of electrical activity in cultured hippocampal slices by a multitransistor array (MTA) with 16,384 elements. Time-resolved imaging is achieved with a resolution of 7.8 microm on an area of 1 mm2 at 2 kHz. A read-out of fewer elements allows an enhanced time resolution. Individual transistor signals are caused by local evoked field… (More)
Patch pipette, (b) oxide-semiconductor field-effect transistor (OSFET). Abstract-A CMOS sensor array for extracellular, high density imaging of electrical activity of living neural networks is presented. The chip is fabricated in an extended 0.5 µm CMOS technology, and provides 128 x 128 pixels with a pitch of 7.8 µm, full frame rate is 2000 frames per… (More)
CMOS-based sensor array chips provide new and attractive features as compared to today's standard tools for medical, diagnostic, and biotechnical applications. Examples for molecule- and cell-based approaches and related circuit design issues are discussed.