Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that codeletion of the p53 and αv integrin genes in mouse… (More)
BACKGROUND AND PURPOSE A dacryocystocele forms when tears accumulate within the lacrimal sac as a result of an obstruction more distally in the lacrimal drainage apparatus, which may occur as a complication of sinonasal surgery. The purpose of this study was to define the imaging characteristics of a postoperative dacryocystocele occurring after surgery for… (More)
Intricate resection and complex reconstructive procedures often required for primary and metastatic orbital tumors are facilitated by accurate imaging. A three-dimensional (3D) image can be reconstructed from source axial multidetector computed tomography (MDCT) images to visualize orbital tumors. To assess the utility of 3D images in this setting, the 3D… (More)
Merkel cell carcinoma (MCC) in the eyelid and periocular region can be treated surgically, in most cases, with preservation of the eye and reasonable visual function. Adjuvant radiation therapy, sentinel lymph node biopsy, and chemotherapy should be considered for MCC of the eyelid and periocular region, especially for larger tumors that are T2b or more… (More)
T argeted treatment with sonic hedgehog inhibitors for locally advanced basal cell carcinoma (BCC) has significantly improved our ability to preserve ocular function and avoid orbital exenteration in patients with locally advanced BCC of orbital and perioribtal area. Epidermal growth factor receptor inhibitors can be considered as non-surgical treatment in… (More)
Ocular surface squamous neoplasia (OSSN) is a common ocular surface tumor with an increased incidence in African countries (3.4 and 3.0 cases/year/100,000). Despite its potential for vision loss and death, OSSN remains largely neglected by both eye and HIV care programs in Africa. The purpose of this review is to identify the barriers to timely diagnosis… (More)
PURPOSE To describe a series of patients with Non-Hodgkin's lymphoma (NHL) and concomitant eyelid carcinoma. METHODS In this non-comparative interventional case series, we retrospectively reviewed the medical records of 5 patients with NHL who developed eyelid carcinoma. RESULTS The patients included one female and four male subjects. Systemic lymphoma… (More)
We herein report a patient with cancer-associated retinopathy who experienced multiple bouts of paraneoplastic retinopathy and optic neuropathy but responded to treatments with alemtuzumab and was able to maintain useful vision over the course of 8 years of follow-up.