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OBJECTIVE Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin(More)
BACKGROUND Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from these twins. METHODOLOGY/PRINCIPAL FINDINGS Skeletal muscle (n = 11 pairs) and subcutaneous(More)
AIMS/HYPOTHESIS We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins. METHODS We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further investigations of selected miRNAs(More)
Supplementary Figure S1 a, qPCR analysis of mRNAs in inguinal (subcutaneous), epididymal (visceral) or interscapular brown fat (BAT) depots for indicated genes. Samples were harvested from mice after three weeks of free wheel running or sedentary controls. The exercised mice were rested for 12 hours prior to analysis. Each group had n=10 mice. b-c, qPCR(More)
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