Birgitta Glenmark

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AIM There are two known oestrogen receptors (ER), oestrogen receptor alpha (ERalpha) and the recently cloned oestrogen receptor beta (ERbeta). ERalpha mRNA has been detected in mouse, rat, bovine and human skeletal muscle. ERbeta mRNA has been detected in bovine skeletal muscle. To our knowledge, no study has investigated the expression of oestrogen(More)
α-Actinin-3 is a Z-disc protein expressed only in type II muscle fibers. A polymorphism in the ACTN3 gene (R577X) results in lack of α-actinin-3 in XX genotype. The prevalence of the mutated X-allele is lower among power/sprint oriented athletes compared with controls, indicating that the lack of α-actinin-3 is detrimental in these sports, but a mechanistic(More)
Age-related changes in muscle fibre characteristics have been presented in cross-sectional studies previously. The aim of the present study was to investigate longitudinally whether the muscle fibre type composition and muscle fibre area change from adolescence to adulthood. Fifty-five men and 28 women were studied at the age of 16 and again at the age of(More)
OBJECTIVE Progressive muscle weakness is a common feature in patients with rheumatoid arthritis (RA). However, little is known about whether the intrinsic contractile properties of muscle fibers are affected in RA. This study was undertaken to investigate muscle contractility and the myoplasmic free Ca2+ concentration ([Ca2+](i)) in the soleus, a major(More)
PURPOSE The purpose of the study was to examine muscle strength and pain sensitivity in postmenopausal women with and without RA. METHODS Ten women with and ten without early RA were recruited. All were postmenopausal, and did not use hormone replacement therapy. Measurements of isokinetic muscle strength in knee flexors/extensors, hand grip strength,(More)
Glenmark, Birgitta, Maria Nilsson, Hui Gao, Jan-Åke Gustafsson, Karin Dahlman-Wright, and Håkan Westerblad. Difference in skeletal muscle function in males vs. females: role of estrogen receptor. Am J Physiol Endocrinol Metab 287: E1125–E1131, 2004. First published July 27, 2004; doi:10.1152/ajpendo.00098. 2004.—Male skeletal muscles are generally faster(More)
To cite: Yamada T, Fedotovskaya O, Cheng AJ, et al. Ann Rheum Dis Published Online First: [please include Day Month Year] doi:10.1136/ annrheumdis-2013-205007 ABSTRACT Objective Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms(More)
It has been shown earlier that the proportion of slow twitch (type I) fibres in the leg musculature is directly related to running performance in boys but not in girls at the age of 16. The purpose of the present study was to determine whether this pattern remains in adulthood. Forty-one men and 19 women were tested at the age of 16 and 27 years. Muscle(More)
OBJECTIVE Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms behind arthritis-induced skeletal muscle weakness with special focus on the role of nitrosative stress on intracellular Ca(2+) handling and specific force production. (More)