Birgit Langhans

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T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of transforming growth factor (TGF)-beta/IL-6 or IL-21, requires expression of the transcription factor retinoic acid receptor-related orphan receptor gamma t (ROR gamma(More)
Area at risk (AAR) is an important parameter for the assessment of the salvage area after revascularization in acute myocardial infarction (AMI). By combining AAR assessment by T2-weighted imaging and scar quantification by late gadolinium enhancement imaging cardiovascular magnetic resonance (CMR) offers a promising alternative to the “classical” modality(More)
BACKGROUND Careful patient selection is the prerequisite to raise transplant benefit. In lung transplant (LT) candidates, the effect of body mass index (BMI) on postoperative outcome remains controversial, possibly due to the inaccuracy of BMI in discriminating between fat and muscle mass. We therefore hypothesized that assessment of body composition by(More)
BACKGROUND Infarct size is an important predictor of cardiac risk after acute myocardial infarction. The established modality for its assessment is Tc99m-Sestamibi Single-photon emission computed tomography (SPECT). In recent years, data are emerging demonstrating that scar size as assessed by late gadolinium enhancement in cardiovascular magnetic resonance(More)
OBJECTIVES This study sought to compare cardiac magnetic resonance (CMR) and single-photon emission computed tomography (SPECT) for assessment of area at risk, scar size, and salvage area after coronary reperfusion in acute myocardial infarction. BACKGROUND Myocardial salvage is an important surrogate endpoint assessing the success of coronary reperfusion(More)
The original publication of the article contains error in the Abstract section. The sentence starting with ‘‘We prospectively analyzed ...’’ should read as ‘‘We prospectively analyzed patients (n = 448) with AMI and primary angioplasty, who underwent contrast-enhanced cardiac magnetic resonance (CMR) imaging on a 1.5 T scanner in median 5 [4, 6] days after(More)
Background Besides total scar size, scar characterization parameters are emerging as additional prognostic factors after acute myocardial infarction. Of these, microvascular obstruction (MVO) and infarct border zone are the most promising ones. Nevertheless, a MRI scan performed few days after infarction assesses a rapidly changing myocardium. In particular(More)
OBJECTIVE To assess biochemical characteristics of adrenarche in patients with myelomeningocele (MMC), we examined serum levels of dehydroepiandrosterone sulfate (DHEAS) in prepubertal MMC patients. PATIENTS AND METHODS The study included a total of 54 prepubertal patients with MMC and shunted hydrocephalus: 13 patients (2 m, 11 f; aged 4.6-10.1 years,(More)
Imaging is a highly attractive option for improved risk stratification, as it allows direct detection and quantification of subclinical and clinical disease burden. Among available imaging techniques, MRI may be particularly suited for comprehensive cardiovascular risk assessment given its non-ionizing nature and high soft-tissue contrast. In this(More)