Birgit Jaeger

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Differential effect of NAT2 on the association between active and passive smoke exposure and breast cancer risk.

Jenny Chang-Claude, Silke Kropp, Birgit Jaeger, H Bartsch, Angela Risch
Cancer epidemiology, biomarkers & prevention : a…
2002

BACKGROUND Polymorphisms in the N-acetyltransferase 2 (NAT2) gene influence the rate of metabolism of aromatic and heterocyclic amines present in tobacco smoke. Because the physicochemical… (More)

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption.

Carmen Lilla, Emaculate Verla-Tebit, +4 authors Jenny Chang-Claude
Cancer epidemiology, biomarkers & prevention : a…
2006

N-Acetyltransferases 1 and 2 (NAT1 and NAT2), both being highly polymorphic, are involved in the metabolism of aromatic and heterocyclic aromatic amines present in cigarette smoke and red meat cooked… (More)

CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences.

Maria N Timofeeva, Silke Kropp, +11 authors Heinz-Erich Wichmann
Carcinogenesis
2009

Cytochrome P450 (CYP) enzymes, involved in metabolism of tobacco carcinogens, are also involved in estrogen metabolism and many are regulated by estrogens. These genes may thus be of relevance to… (More)

Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.

Maria N Timofeeva, Silke Kropp, +11 authors H Wichmann
International journal of cancer
2010

Early-onset lung cancer diagnosed up to the age of 50 is a very rare disease, with an increasing incidence rate. Differences in aetiology, characteristics and epidemiology of early and older onset… (More)

Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility.

Harriet Wikman, Steffen Thiel, +9 authors Angela Risch
Pharmacogenetics
2001

The highly polymorphic N-acetyltransferases (NAT1 and NAT2) are involved in both activation and inactivation reactions of numerous carcinogens, such as tobacco derived aromatic amines. The potential… (More)

The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose.

Heike Dally, Lutz Edler, +8 authors Angela Risch
Pharmacogenetics
2003

CYP3A isozymes are involved in tobacco carcinogen- and steroid-metabolism, and are expressed in human lung tissue showing interindividual variation in expression and activity. The CYP3A4*1B allele… (More)

Genotype relationships in the CYP3A locus in Caucasians.

Heike Dally, Helmut Bartsch, +8 authors Angela Risch
Cancer letters
2004

Genetic polymorphisms of the human CYP3A family affect clinical drug efficacy and may modify cancer risk. CYP3A genes show high sequence similarity that had previously lead to misallocation of CYP3A… (More)

Eprosartan versus enalapril in elderly patients with hypertension: a double-blind, randomized trial.

Luis M Ruilope, Birgit Jaeger, Benjamin A. Prichard
Blood pressure
2001

AIM To compare the efficacy and safety of eprosartan and enalapril to lower systolic blood pressure in elderly patients with essential hypertension. METHODS 334 patients >65 years with sitting… (More)

A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers.

Maria N Timofeeva, Birgit Jaeger, +4 authors Angela Risch
Clinical biochemistry
2009

OBJECTIVES Deletion polymorphisms of Glutathione-S-transferase (GST) M1 and T1 are considered risk factors for various diseases. However, most previous studies only distinguished "null" and… (More)

[2 nonparametric statistical tests for small-size samples].

K. E. Biebler, Birgit Jaeger, Cytophotometry Voss
Zeitschrift fur arztliche Fortbildung
1986

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