Birgit Holzapfl

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Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal–oxide–semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 m 7.8 m for imaging of(More)
A fully electronic medium density DNA micro array is presented using a CMOS process extended by gold electrodes. The chip provides 128 sensor sites, in-sensor site current-mode A/D conversion, peripheral circuitry including bandgap and current references, D/A-converters to provide electrode bias voltages, calibration circuitry, and a 6 pin interface for(More)
A CMOS sensor array for extracellular, high density imaging of electrical activity of living neural networks is presented. The chip is fabricated in an extended 0.5 μm CMOS technology, and provides 128 x 128 pixels with a pitch of 7.8 μm, full frame rate is 2000 frames per second. Dynamic maps from single cells and cultured networks are shown. I. I.(More)
A sensor for electrical detection of DNA is fabricated in a CMOS production line. A gold deposition process module is integrated in a CMOS backend process. The sensor principle is based on immobilization of singlestranded DNA probe molecules on an array consisting of interdigitated gold lines and subsequent hybridization with labeled target DNA strands. The(More)
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