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Proteome survey reveals modularity of the yeast cell machinery

• Anne-Claude Gavin, Patrick Aloy, +29 authors Giulio Superti-Furga
• Nature
• 2006

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, budding… (More)

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

• Marcus Bantscheff, Carsten Hopf, +21 authors Gerard Drewes
• Nature Biotechnology
• 2011

The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and anti-inflammatory properties remains challenging in large part owing to the difficulty of probing the… (More)

Femtomol sensitivity post-digest (18)O labeling for relative quantification of differential protein complex composition.

• Marcus Bantscheff, Birgit Duempelfeld, Bernhard Küster
• Rapid communications in mass spectrometry : RCM
• 2004

Stable isotope labeling (SIL) has emerged as a powerful tool to measure the relative quantitative differences between samples in many differential display-type proteomic applications. However,… (More)

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

• Edith Winkler, Scott Hobson, +6 authors Harald Steiner
• Biochemistry
• 2009

Gamma-secretase is a unique intramembrane-cleaving protease complex, which cleaves the Alzheimer's disease-associated beta-amyloid precursor protein (APP) and a number of other type I membrane… (More)

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.

• Douglas Thomson, Anne J Wagner, +14 authors Marcel Muelbaier
• Journal of medicinal chemistry
• 2017

The availability of high quality probes for specific protein targets is fundamental to the investigation of their function and their validation as therapeutic targets. We report the utilization of a… (More)

An improved two-step calibration method for matrix-assisted laser desorption/ionization time-of-flight mass spectra for proteomics.

• Marcus Bantscheff, Birgit Duempelfeld, Bernhard Küster
• Rapid communications in mass spectrometry : RCM
• 2002

Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags.

• Carsten Hopf, Dirk Eberhard, Markus Boesche, Sonja Bastuck, Birgit Duempelfeld, Marcus Bantscheff
• Methods in molecular biology
• 2012

Chemical proteomics offers a unique approach for target identification of small molecule inhibitors directly from cell extracts, thus enabling characterization of target proteins under close to… (More)

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