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An impaired immune response is frequently observed in patients and experimental animals with advanced cancer. We and others have shown alterations in CD3-associated signal-transducing molecules in tumor-infiltrating T cells and peripheral blood lymphocytes (PBLs) of patients with advanced cancer. By using flow cytometric analysis of per-meabilized cells(More)
It is increasingly recognized that business models offer an abstraction that is useful not only in the exploration of new business networks but also for the design and redesign of operational business processes. Among others, they can be used as input for a risk analysis that is crucial in cross-organizational business process design. However, the notion of(More)
In this paper, a declarative foundation for process models is proposed. Three issues in process management and modeling are identified: business orientation, traceability, and flexibility. It is shown how these issues can be addressed by basing process models on business models, where a business model focuses on the transfer of value between agents. As a(More)
Organizations of today are becoming ever more focused on their business processes. This has resulted in an increasing interest in using best practices for business process reengineering. Two problems arise in connection to using best practices: how to find a best practice that suits particular purposes, and how to ensure that the process from the best(More)
The increasing interest in process engineering and application integration has resulted in the appearance of various new process modelling languages. Understanding and comparing such languages has therefore become a major problem in information systems research and development. We suggest a framework to solve this problem involving several instruments: a(More)
In keeping with the proliferation of free software development initiatives and the increased interest in the business process management domain, many open source workflow and business process management systems have appeared during the last few years and are now under active development. This upsurge gives rise to two important questions: what are the(More)
In this paper we discuss the problem of how to go from a business model to a process model in a systematic way. Business models are economic models used for business analysis, while process models capture low-level business activities and their coordination. We propose a method that starts with a business model where the main actors and their relationships(More)
To create an understanding of enterprises and the ways they do business, a starting point could be to identify the main actors and the values transferred between them. Business models are created in order to make clear who the business actors are in a business case and to make their relations explicit. The relations are formulated in terms of values(More)