Birendra Kumar Prusty

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BACKGROUND Apoptosis of several host cells induced by parasites/parasite products has been investigated in human filariasis to understand immune hyporesponsiveness. However, apoptosis of monocytes-one of the major antigen presenting cells in peripheral circulation, which are chronically exposed to filarial antigens in infected subjects-is yet to be(More)
Acetaminophen (N-acetyl-para-aminophenol (APAP)) toxicity causes acute liver failure by inducing centrilobular hepatic damage as a consequence of mitochondrial oxidative stress. Sterile inflammation, triggered by hepatic damage, facilitates gut bacterial translocation leading to systemic inflammation; TLR4-mediated activation by LPS has been shown to have a(More)
Syphacia obvelata infection was diagnosed in mice during routine health monitoring of rodent colony at Animal Facility, ILSNISER, Bhubaneswar. Entire mice colony was treated with fenbendazole mixed in drinking water @70 mg / liter in combination with topical spray of injectable 0.1 % ivermectin solution to arrest the disease. At the same time mice were(More)
Nitric oxide performs a wide variety of versatile functions in the immune system. But it's precise role in the pathogenesis of acute inflammation and sepsis is still controversial. In the present study, we demonstrate a novel mutation in nitric oxide synthase interacting protein (NOSIP) and its association with mortality in sepsis. We also show direct(More)
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