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BACKGROUND/AIM Interleukin-8 (IL-8), a potent chemoattractant for neutrophils, has been implicated in the pathogenesis of Alzheimer's disease (AD). The ability of individuals to produce high levels of IL-8 is partially determined by the IL-8 -251 T/A polymorphism. Therefore, we investigated the association between this polymorphism and AD in a Chinese(More)
The receptor for advanced glycation end products (RAGE) is associated with several pathological states including Alzheimer’s disease (AD) pathology, while its soluble form (sRAGE) acts as a decoy receptor. We have tested for association of AD with a functional single-nucleotide polymorphism (SNP) in the RAGE gene (G82S; rs2070600), a SNP associated with(More)
BACKGROUND In Heilongjiang province, the HIV prevalence in men who have sex with men (MSM) is generally lower than other part of China. However, the official perception for their risk of HIV/AIDS infection has been increasing in the province over the years. Moreover, little information on HIV/AIDS was provided to the communities so that we have disadvantage(More)
  • Yingxin Pei, Jun Terajima, +10 authors Haruo Watanabe
  • Japanese journal of infectious diseases
  • 2008
We identified seven distinct subtypes of enterohemorrhagic Escherichia coli (EHEC) O157:H7 isolates that were derived from sporadic cases and outbreaks from multiple prefectures in Japan in 2005. A surveillance system utilizing pulsed-field gel electrophoresis (PFGE), PulseNet Japan, was used. Some strains showed indistinguishable PFGE patterns using(More)
BACKGROUND To monitor the prevalence of HIV and syphilis as well as behaviours, a sentinel site for men who have sex with men was established in Harbin in 2002. With additional funding, the sentinel surveillance evolved into annual cross-sectional surveys since 2006. METHODS Behavioural and serological data collected in five consecutive cross-sectional(More)
OBJECTIVE To investigate the characteristics and trends of the HIV epidemic in Heilongjiang province of China between 1993 and 2012. METHODS Data from the provincial surveillance system for HIV infections and AIDS were reviewed. Local health staff reviewed medical records, including dates of HIV/AIDS diagnoses and deaths, exposure category, treatment,(More)
AIMS (1) To determine the incidence of type 1 diabetes mellitus in children aged<15 years in Harbin, China and (2) to examine the trend in incidence over the period from 1990 to 2000. METHODS Newly diagnosed cases of type 1 diabetes from 1990 to 2000 were identified among 1,286,154 Chinese children aged 0-14 years in Harbin. The primary source of case(More)
BACKGROUND Interleukin-8 (IL-8), a CXC chemokine that recruits and activates inflammatory cells, plays a critical role in the pathogenesis of ulcerative colitis (UC). There are no studies on the association of single nucleotide polymorphisms (SNPs) of the IL-8 gene with the risk of UC. METHODS All 162 unrelated UC patients and 203 control subjects were(More)
Leptin receptor (LEPR) plays an important physiological role in energy metabolism. The study addressed the relationship between leptin receptor gene variations and type 2 diabetes mellitus (T2DM). Three single nucleotide polymorphisms (SNPs) of LEPR gene, Arg109Lys (A/G), Asn656Lys (C/G) and Pro1019Pro (C/T) were detected in a northern population in China.(More)
1Institute of Genetics and Developmental Biology, Graduate School of the Chinese Academy Sciences, Beijing 100101, People’s Republic of China 2Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, People’s Republic of China 3National Institute of Geriatric Medicines, Beijing Hospital, Ministry of Health, Beijing(More)