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BACKGROUND Protease serine 8 (PRSS8), a trypsin-like serine peptidase, has been shown to function as a tumour suppressor in various malignancies. The present study aimed to investigate the expression pattern, prognostic value and the biological role of PRSS8 in human hepatocellular carcinoma (HCC). METHODS PRSS8 expression in 106 HCC surgical specimens(More)
Breast cancer side population (SP) cells display distinctly higher CXCR4 and ABCG2 expression levels, sphere formation efficiency (SFE), and growth capacity, even under hypoxic conditions. Inhibition of CXCR4 by the inhibitor AMD3100 suppressed SFE and cell growth under hypoxia. ABCG2 confers the major phenotype of SP cells, and knockdown of ABCG2 also(More)
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