Binita Koirala Sharma

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These experiments were performed to characterize the relationship between lipid peroxidation and hepatocyte viability in iron overload. Hepatocytes were isolated from rats with chronic dietary iron overload and the effects of in vitro iron chelation on lipid peroxidation, cell viability and ultrastructure were studied over a 4-hr incubation period. Cell(More)
Purpose: To investigate the effect of the aqueous extract of Zingiber officinale Roscoe. (ZOA) rhizome on the activity and expression of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 using an in vitro model of Dengue virus (DV) infection. Methods: Z. officinale rhizomes were extracted with water by(More)
The role of matrixmetalloproteinase (MMP)-2 and MMP-9 in vascular leakage associated with dengue haemorrhagic fever and MMPs regulation by tissue inhibitor of metalloproteinases (TIMPs) has been established. Control of MMPs and TIMPs activity is of great significance to prevent vascular leakage caused by dengue virus (DV) infection. Gingerol (Zingiber(More)
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