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CAD has been traditionally used to assist in engineering design and modeling for representation, analysis and manufacturing. Advances in Information Technology and in Biomedicine have created new uses for CAD with many novel and important biomedical applications, particularly tissue engineering in which CAD based bio-tissue informatics model provides(More)
One of the critical functions of a tissue-engineered construct is to be able to provide adequate nutrient and oxygen supply into the interior of the construct. An insufficient supply will lead to slower cellular proliferation rates and eventual apoptosis. The supply of the nutrients is largely governed by the transport properties of the construct which in(More)
The technology of digital image guidance systems has transformed many aspects of neurosurgery, including intracranial tumor surgery, functional neurosurgery, and spinal surgery. Despite the central role of imaging studies in diagnosis and treatment planning, intraoperative image guidance has so far had very limited application to the surgical correction of(More)
Modeling, design and fabrication of tissue scaffolds with intricate architecture, porosity and pore size for desired tissue properties presents a challenge in tissue engineering. This paper will present the details of our development in the design and fabrication of the interior architecture of scaffolds using a novel design approach. The interior(More)
Performance of various functions of the tissue structure depends on porous scaffold microstructures with specific porosity characteristics that influence the behavior of the incorporated or ingrown cells. Understanding the mechanical properties of porous tissue scaffold is important for its biological and biomechanical tissue engineering application. This(More)
Guided tissue regeneration is gaining importance in the field of orthopaedic tissue engineering as need and technology permits the development of site-specific engineering approaches. Computer Aided Design (CAD) and Finite Element Analysis (FEA) hybridized with manufacturing techniques such as Solid Freeform Fabrication (SFF), is hypothesized to allow for(More)
Direct slicing of CAD models to generate process planning instructions for solid freeform fabrication may overcome inherent disadvantages of using stereolithography format in terms of the process accuracy, ease of file management, and incorporation of multiple materials. This paper will present the results of our development of a direct slicing algorithm(More)
  • C Gomez, Sun, Connie Gomez, Binil Starly, Ali Shokoufandeh, Wei Sun
  • 2006
The following item is made available as a courtesy to scholars by the author(s) and Drexel University Library and may contain materials and content, including computer code and tags, artwork, text, graphics, images, and illustrations (Material) which may be protected by copyright law. Unless otherwise noted, the Material is made available for non profit and(More)
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