Binglin Wang

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Using high concentration biochemical assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 was equipotent for ROCK1 (IC(50) = 650 nM) and ROCK2 (IC(50) = 670 nM), whereas compound 24 was more selective for ROCK2 (IC(50) = 100 nM) over ROCK1 (IC(50) = 1690 nM). The crystal(More)
ROCK1 and ROCK2 mediate important processes such as cell migration, invasion and metastasis, making them good targets for the development of antitumor agents. Recently, using a fragment-based approach and X-ray crystallography, we reported on the design and synthesis of novel Rho-kinase inhibitors (RKIs). Here, we selected a pair of RKIs, the closely(More)
The environmental science communities are actively engaged in developing the next generation of large-scale sensor based field observing systems. The challenges that these systems face are listed as below: complexity of sensor data stream processing and effects of web-based real-time data display. In this paper, we utilized the RBNB DataTurbine, an(More)
In the field ecological data collection process, lots of heterogeneous data are generated by equipments which are composed of hundreds to thousands of sensors and cameras and it is a big challenge to collect and manage these data. In this paper, we proposed a five layer framework named FEDC which can be used in the field ecological data collection and(More)
In this paper, we proposed a semi-distributed transportation and management network for field ecological data collection. We developed the semi distributed transportation network to transmit the real-time video data and real-time flux data in the ChinaFlux [1] project, and utilized the SRB technique to manage the distributed ecological data among different(More)
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