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Human–Agent Collaboration for Time-Stressed Multicontext Decision Making
- Xiaocong Fan, M. McNeese, Bingjun Sun, T. Hanratty, L. Allender, J. Yen
- Computer ScienceIEEE Transactions on Systems, Man, and…
- 1 March 2010
The statistical inference of experimental results indicates that R-CAST agents can significantly improve the performance of C2 teams in multicontext decision making under varying time-stressed situations.
Self-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer Chemotherapy.
This novel prodrug-nanosystem addresses concerns related to the low drug loading and inefficient drug release from hydrophobic prodrugs of PTX, and provides possibilities for the development of redox dual-sensitive conjugates or polymers for efficient anticancer drug delivery.
High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy.
A polymeric nanoparticle system that contains both a chemotherapeutic agent and a photosensitizer to seek improvement for chemo-photodynamic therapy and reduced off-target toxicity is designed.
Topic segmentation with shared topic detection and alignment of multiple documents
A novel unsupervised method for shared topic detection and topic segmentation of multiple similar documents based on Mutual information (MI) and weighted mutual information (WMI) that is a combination of MI and term weights.
Prodrug-based nanoparticulate drug delivery strategies for cancer therapy.
Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine.
This redox-responsive prodrug-nanosystem demonstrates multiple therapeutic advantages, including one-step facile fabrication, high drug-loading efficiency, on-demand drug release responding to redox stimuli, as well as favorable cellular uptake and biodistribution, which result in significantly enhanced antitumor efficacy in vivo.
Light-activatable dual-source ROS-responsive prodrug nanoplatform for synergistic chemo-photodynamic therapy.
The design and synthesis of a ROS-triggered prodrug nanoplatform fabricated with oxidation-responsive cabazitaxel (CTX) prodrugs for synergistic chemo-photodynamic therapy, thioether-/selenoether-linked conjugates of CTX and oleic acid (OA) is reported.
Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergistic Therapy Against Drug-sensitive and Multidrug-resistant Breast Cancer.
Overall, encapsulation of hydrophobic drugs, such as TET, in reduction-sensitive PTX-SS-VE nanoparticles provides a prospective strategy to effectively overcome the multidrug resistance of tumor cells in a synergistic manner.
Extraction and search of chemical formulae in text documents on the web
Experiments show that the approaches to chemical formula extraction work well, especially after trade-off tuning, and demonstrate that feature selection can reduce the index size without changing ranked query results much.
The role of particle size of glyburide crystals in improving its oral absorption
- Yongjun Wang, Wenqian Yang, Zhonggui He
- Materials Science, ChemistryDrug Delivery and Translational Research
- 31 March 2017
It is confirmed that nanosizing has a tremendous impact on promoting the oral absorption of glyburide and in vitro and in vivo characterizations of drug crystals during the nanosized process.