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Finite element (FE) models are frequently used in engineering and life sciences within time-consuming simulations. In contrast with the regular grid structure facilitated by volumetric data sets, as used in medicine or geosciences, FE models are defined over a non-uniform grid. Elements can have curved faces and their interior can be defined through(More)
The effectiveness of direct volume rendered images depends on finding transfer functions which emphasize structures in the underlying data. In order to support this process, we present a spreadsheet-like constructive visual component-based interface, which also allows novice users to efficiently find meaningful transfer functions. The interface uses a(More)
Nadph oxidase 4 is an important cellular source of reactive oxygen species (ROS) generation in the kidney. Novel antioxidant drugs, such as Nox4 inhibitor compounds, are being developed. There is, however, very little experimental evidence for the biological role and regulation of Nadph oxidase isoforms in the kidney. Herein, we show that Fulvene-5 is an(More)
The renal epithelial sodium channel (ENaC) provides regulated sodium transport in the distal nephron. The effects of intracellular calcium ([Ca(2+)]i) on this channel are only beginning to be elucidated. It appears from previous studies that the [Ca(2+)]i increases downstream of ATP administration may have a polarized effect on ENaC, where apical(More)
The UT-A1 urea transporter plays an important role in the urinary concentration mechanism. However, the molecular mechanisms regarding UT-A1 trafficking, endocytosis, and degradation are still unclear. In this study, we identified the small GTPase Rab14 as a binding partner to the C terminus of UT-A1 in a yeast 2-hybrid assay. Interestingly, UT-A1 binding(More)
Direct Volume Rendering of Finite Element models is challenging since the visualisation process is performed in world coordinates, whereas data fields are usually defined over the elements' material coordinate system. In this paper we present a framework for Direct Volume Rendering of Finite Element models. We present several novel implementations(More)