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OBJECTIVE To monitor the level of phthalates in human biological samples. METHODS The concentrations of three commonly-used phthalate (di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP; di-2-ethylhexyl phthalate, DEHP) in the human biological samples were measured by using reversed-phase HPLC. The blood serum samples were collected from 52 women and 8(More)
OBJECTIVE To investigate the effect of ambient air pollution on human health and the subsequent disability-adjusted life years (DALYs) lost in Shanghai. METHODS We used epidemiology-based exposure-response functions to calculate the attributable number of cases due to air pollution in Shanghai in 2000, and then we estimated the corresponding DALYs lost in(More)
OBJECTIVE To monitor the level of phthalates in human semen samples and to analyze the relationship between phthalate levels and semen parameters. METHODS Concentrations of three kinds of commonly used phthalates (di-ethyl phthalate, DEP; di-n-butyl phthalate, DBP; di-2-ethylhexyl phthalate, DEHP) were measured using reversed-phase HPLC. Semen parameters(More)
Phthalates are suspect environmental endocrine disruptors that may affect male reproduction and development by disturbing androgen synthesis and cell-cell interactions in the seminiferous epithelium. The in vivo metabolites, monophthalates, are thought to be the active agents, and toxicant effects including testicular damage and decreased sperm motility(More)
OBJECTIVE To investigate the association between temperature and daily mortality in Shanghai from June 1, 2000 to December 31, 2001. METHODS Time-series approach was used to estimate the effect of temperature on daily total and cause-specific mortality. We fitted generalized additive Poisson regression using non-parametric smooth functions to control for(More)
There is a growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy. The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood. The current study was designed to assess in utero exposure(More)
OBJECTIVE To investigate the relation between air pollution exposure and preterm birth in Shanghai, China. METHODS We examined the effect of ambient air pollution on preterm birth using time-series approach in Shanghai in 2004. This method can eliminate potential confounding by individual risk factors that do not change over a short period of time. Daily(More)
OBJECTIVE To obtain the exposure-response functions that could be used in health-based risk assessment of particulate air pollution in China. METHODS Meta analysis was conducted on the literatures on air particulate matter and its adverse health outcomes in China and worldwide. RESULTS For each health outcome from morbidity to mortality changes, the(More)
OBJECTIVE To determine the best statistical distribution of concentration data of major air pollutants in Shanghai. METHODS Four types of theoretic distributions (lognormal, gamma, Pearson V and extreme value) were chosen to fit daily average concentration data of PM10, SO2 and NO2 from June 1, 2000 to May 31, 2003 in Shanghai by using the maximum(More)
OBJECTIVE To examine the effect of particulate matter (PM) less than 10 microns in diameter (PM10) and ozone (O3) on daily mortality in Shanghai, China. METHODS A generalized additive model with penalized spline function was used to observe the acute effect of PM10 and O3 on daily mortality. RESULTS Higher PM10 significantly increased the effect of O3(More)