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Population Survey of CCR5 &Dgr;32, CCR5 m303, CCR2b 64I, and SDF1 3´A Allele Frequencies in Indigenous Chinese Healthy Individuals, and in HIV-1-Infected and HIV-1-Uninfected Individuals in HIV-1
This finding is the first reporting that there is likely no effect of the examined polymorphisms in this study on HIV-1 transmission in the Chinese Han population, which may be helpful for studies of specific anti-HIV-1 vaccine trials and coreceptor inhibitor drug targets in Chinese populations. Expand
Estradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke
It is demonstrated for the first time that E2 replacement in ovariectomized female mice improves stroke-induced peripheral immunosuppression. Expand
Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo.
Autologous CIK cells are of highly efficient cytotoxic effector cells against primary hepatocellular carcinoma cells and might serve as an alternative adoptive therapeutic strategy for HCC patients. Expand
Immunoglobulin and T cell receptor gene high-throughput sequencing quantifies minimal residual disease in acute lymphoblastic leukemia and predicts post-transplantation relapse and survival.
The use of HTS-based MRD quantification in adults with ALL offers a standardized approach with sufficient sensitivity to quantify leukemia MRD in peripheral blood and may identify a window for clinical intervention before overt relapse. Expand
Asprosin improves the survival of mesenchymal stromal cells in myocardial infarction by inhibiting apoptosis via the activated ERK1/2-SOD2 pathway.
It is demonstrated that ASP protects MSCs from oxidative stress-induced apoptosis via the ERK1/2-SOD2 pathway, the first evidence that ASP can regulate M SCs function and enhance MSCS therapy for ischemic heart disease. Expand
Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma.
It is indicated that autologous CIK cells can efficiently improve the immunological status in HCC patients, and may provide a potent approach for H CC patients as the adoptive immunotherapy. Expand
Recombinant T Cell Receptor Ligand Treats Experimental Stroke
These data are the first to demonstrate successful treatment of experimental stroke using a neuroantigen-specific immunomodulatory agent administered after ischemia, suggesting therapeutic potential in human stroke. Expand
Early pregnancy factor treatment suppresses the inflammatory response and adhesion molecule expression in the spinal cord of SJL/J mice with experimental autoimmune encephalomyelitis and the
Early pregnancy factor (EPF) is a secreted protein, present in serum during early pregnancy and essential for maintaining viability of the embryo. It is a homologue of chaperonin 10 (Cpn10) but,Expand
Nuclear factor-κB and apoptosis in patients with intracerebral hemorrhage
Observations indicate that apoptosis has a major role in pathological cell death after ICH and that activation of NF-κB is positively related to the progress of apoptosis. Expand
Early pregnancy factor suppresses the infiltration of lymphocytes and macrophages in the spinal cord of rats during experimental autoimmune encephalomyelitis but has no effect on apoptosis
It is suggested that EPF treatment reduces the numbers of lymphocytes and macrophages in the CNS, possibly through an effect on cell trafficking. Expand