Learn More
Breast cancer produces a variety of growth factors to promote its behavior at primary and secondary sites in autocrine/paracrine manners. However, the role of these growth factors in the colonization of cancer cells in bone, which is one of the most common metastatic sites, is poorly understood. To study this, we established an in vivo model in which the(More)
AIMS Aberrant vascular smooth muscle cell (VSMC) proliferation and migration contribute significantly to the development of vascular pathologies, such as atherosclerosis and restenosis. MicroRNAs have recently emerged as critical modulators in cellular processes and the purpose of this study is to identify novel miRNA regulators implicated in human aortic(More)
AIM to determine the efficacy and toxicities of sorafenib in the treatment of patients with multiple recurrences of hepatocellular carcinoma (HCC) after liver transplantation in a Chinese population. METHODS twenty patients with multiple recurrences of HCC after liver transplantation were retrospectively studied. They received either transarterial(More)
• We present a new shape recognition method by iterative slippage analysis. • The exact normal is found to be one of the key points for slippage analysis. • The appropriate region is found to be the other key points for slippage analysis. • A knowledge guided region growing method is used to get the appropriate region. • An iterative normal modification(More)
The autoimmune regulator (Aire) gene plays an essential role in negative selection of T cells and deletion of autoreactive T cells in the thymus. The defect in thymic selection in Aire(-/-) mice was attributed to the repressed expression of tissue-specific Ags in the thymic epithelial cells and defective Ag presentation; however, the molecular mechanism(More)
Mammalian sterile 20-like kinase 1 (Mst1) is a critical component of the Hippo signaling pathway, which regulates a variety of biological processes ranging from cell contact inhibition, organ size control, apoptosis and tumor suppression in mammals. Mst1 plays essential roles in the heart disease since its activation causes cardiomyocyte apoptosis and(More)
Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease whose pathogenesis is associated with activation of multiple signaling pathways including Jun NH2-terminal kinases (JNK) and NF-κB. It is now well recognized that these pathways are chaperoned by the heat shock protein 90 (Hsp90), suggesting that inhibition of Hsp90 may be a novel(More)
Activation of signal transducers and activators of transcription (STAT) proteins may be critical to their oncogenic functions as demonstrated by the development of B-cell lymphoma/leukemia in transgenic (TG) mice overexpressing a constitutively activated form of Stat5b. However, low incidence of CD8(+) T cell lymphoma was observed in B6 transgenic mice(More)
Due to the rapid development of computer, sensor, and automatic control technologies, the amount of data generated during product design and manufacturing is increasing significantly. The product data bank is large, complex, heterogeneous, and often fast-changing; it is difficult to integrate heterogeneous models using the conventional method. Therefore, a(More)
In this paper, We evaluate the performance of Anti-collision Algorithm of RFID system. we research dynamic framed slotted algorithm (DFSA) based on EPC Gen2 protocol based on this we studied a kind of framed time slot improvement algorithm (EDFSA) this algorithm absorb the merit of dynamic framed time slot algorithm , this algorithm solve the problem. When(More)